ArticleBrain and behavior2021
Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses.
Article in Brain and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Psychosocial factors and the risk of cancer: An individual-participant data meta-analysis.Cancer · 2026Pooled it
- Longitudinal Risk Factors for Incident Lung Cancer Among a Mixed HIV Serostatus Cohort of Sexual Minority Men in the United States.AIDS education and prevention : official publication of the International Society for AIDS Education · 2026Article
- Insomnia Proven to be Associated With Prostate Cancer: A Genetic Correlation Study Incorporating Lifestyle Factors.Alpha psychiatry · 2025Article
- Estimating additive interaction in 2-stage individual participant data meta-analysis.American journal of epidemiology · 2025Article
- Lived experiences and coping strategies among cancer patients in the Volta Region of Ghana: A health facility-based qualitative study.PLOS mental health · 2025Article
- Impact of Defense Mechanism Styles on Disease Progression in Patients with Gastrointestinal Cancer: Focusing on Clinical Staging.Journal of gastrointestinal cancer · 2024Article
- Loneliness as a predictor of mortality in cancer patients, a cohort studyBiomedica : revista del Instituto Nacional de Salud · 2024Article
- Opportunities for improving data sharing and FAIR data practices to advance global mental health.Global mental health (Cambridge, England) · 2023Review
- Dissecting the Association of Genetically Predicted Neuroticism with Coronary Artery Disease: A Two-Sample Mendelian Randomization Study.Journal of personalized medicine · 2022Article
- Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses.Brain and behavior · 2021Article
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Authors and funding
49 authors.
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Abstract
objectivesPsychosocial factors have been hypothesized to increase the risk of cancer. This study aims (1) to test whether psychosocial factors (depression, anxiety, recent loss events, subjective social support, relationship status, general distress, and neuroticism) are associated with the incidence of any cancer (any, breast, lung, prostate, colorectal, smoking-related, and alcohol-related); (2) to test the interaction between psychosocial factors and factors related to cancer risk (smoking, alcohol use, weight, physical activity, sedentary behavior, sleep, age, sex, education, hormone replacement therapy, and menopausal status) with regard to the incidence of cancer; and (3) to test the mediating role of health behaviors (smoking, alcohol use, weight, physical activity, sedentary behavior, and sleep) in the relationship between psychosocial factors and the incidence of cancer.
methodsThe psychosocial factors and cancer incidence (PSY-CA) consortium was established involving experts in the field of (psycho-)oncology, methodology, and epidemiology. Using data collected in 18 cohorts (N = 617,355), a preplanned two-stage individual participant data (IPD) meta-analysis is proposed. Standardized analyses will be conducted on harmonized datasets for each cohort (stage 1), and meta-analyses will be performed on the risk estimates (stage 2).
conclusionPSY-CA aims to elucidate the relationship between psychosocial factors and cancer risk by addressing several shortcomings of prior meta-analyses.
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