Evidence map›Paper›PMID 34473350›Full record

Trial reportClinical and experimental immunology2021

Dynamics of circulating dendritic cells and cytokines after kidney transplantation-No effect of remote ischaemic conditioning.

Marie B Nielsen, Kristian Ravlo, Marco Eijken, Nicoline V Krogstrup, Morten Bue Svendsen, Chadi Abdel-Halim, Mikkel Steen Petersen, Henrik Birn, Mihai Oltean, Bente Jespersen and 1 more

Open access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Clinical and experimental immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Trial
  2. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Marie B NielsenDepartment of Renal Medicine, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0003-3587-6638
Kristian RavloDepartment of Renal Medicine, Aarhus University Hospital, Aarhus, Denmark.
Marco EijkenDepartment of Renal Medicine, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0002-9043-3971
Nicoline V KrogstrupDepartment of Renal Medicine, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0001-7144-730X
Morten Bue SvendsenDepartment of Renal Medicine, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0002-3544-5769
Chadi Abdel-HalimDepartment of Otorhinolaryngology, Head and Neck Surgery, and Audiology, Odense University Hospital, Odense, Denmark.ORCID 0000-0003-3029-6204
Mikkel Steen PetersenDepartment of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0001-7760-6797
Henrik BirnDepartment of Renal Medicine, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0003-3715-7266
Mihai OlteanThe Transplant Institute, Sahlgrenska University Hospital, Gothenburg, Sweden.ORCID 0000-0003-3783-5207
Bente JespersenDepartment of Renal Medicine, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0001-7196-2870
Bjarne K MøllerDepartment of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0003-2808-4755
Aarhus University Hospital · DKAarhus University · DKOdense University Hospital · DKSahlgrenska University Hospital · SE

Funding

Aarhus UniversitetAarhus UniversitetshospitalA.P. Møller og Hustru Chastine Mc-Kinney Møllers Fond til almene FormaalDansk Nefrologisk SelskabDet Frie ForskningsrådInstitut for Klinisk Medicin, Aarhus UniversitetLundbeckfondenNovo Nordisk FondenNyreforeningenSveriges Läkarförbund
6 · The paper itself

Abstract

Inflammation resulting from ischaemia/reperfusion injury can cause kidney graft dysfunction, increase the risk of delayed graft function and possibly reduce long-term graft survival. Remote ischaemic conditioning may protect against ischaemia/reperfusion injury and mitigate the immunological response to the graft. We investigated the immunological effects of remote ischaemic conditioning on kidney transplantation from deceased donors in the randomized CONTEXT study. Three circulating dendritic cell (DC) subtypes identified in peripheral blood from kidney transplant recipients [myeloid DCs, plasmacytoid DCs and immunoglobulin-like transcript (ILT)3

Indexed as

CytokinesDendritic CellsIschemic PreconditioningKidney TransplantationAdultCell CountFemaleHumansMaleMiddle AgedCytokinescytokinesdendritic cellsimmunologykidney transplantationremote ischaemic conditioning

Identifiers

PMID34473350
PMCPMC8506117
OpenAlexW3197925515

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.