Evidence map›Paper›PMID 34473324›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2022

Testing for Thyroid Peroxidase and Antineuronal Antibodies in Depression and Schizophrenia.

Johann Steiner, Winfried Stoecker, Bianca Teegen, Henrik Dobrowolny, Gabriela Meyer-Lotz, Katrin Borucki, Paul C Guest, Hans-Gert Bernstein

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Johann SteinerLaboratory of Translational Psychiatry, University of Magdeburg, Magdeburg, Germany. johann.steiner@med.ovgu.de.
Winfried StoeckerInstitute for Experimental Immunology, Affiliated to EUROIMMUN AG, Luebeck, Germany.
Bianca TeegenInstitute for Experimental Immunology, Affiliated to EUROIMMUN AG, Luebeck, Germany.
Henrik DobrowolnyLaboratory of Translational Psychiatry, University of Magdeburg, Magdeburg, Germany.
Gabriela Meyer-LotzLaboratory of Translational Psychiatry, University of Magdeburg, Magdeburg, Germany.
Katrin BoruckiInstitute of Clinical Chemistry and Pathobiochemistry, University of Magdeburg, Magdeburg, Germany.
Paul C GuestLaboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil.
Hans-Gert BernsteinLaboratory of Translational Psychiatry, University of Magdeburg, Magdeburg, Germany.
University Hospital Magdeburg · DEEuroimmun Medizinische Labordiagnostika (Germany) · DEUniversidade Estadual de Campinas (UNICAMP) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dietary interventions and physical exercise may improve some symptoms in mental illnesses such as major depression and schizophrenia. Hashimoto's thyroiditis is a known risk factor for these conditions and is marked by the presence of circulating antibodies to thyroid peroxidase (TPO) and thyroglobulin (TG). This chapter presents a protocol to determine if patients with major depression or schizophrenia contain high circulating levels of these antibodies relative to healthy controls. We also describe a procedure testing for the presence of other circulating biomarkers related to brain function, including antibodies directly related to neuronal function. This analysis was performed by screening biochip mosaics of frozen tissue sections and transfected HEK293 cells expressing target antigens using patient and control sera. Finally, we describe a correlation analysis of these markers with symptom scores at baseline and after 6 weeks treatment of the patients using antipsychotics or antidepressants as appropriate.

Indexed as

DepressionIodide PeroxidaseSchizophreniaAutoantibodiesCase-Control StudiesHEK293 CellsHumansAutoantibodiesIodide PeroxidaseDepressionHashimoto thyroiditisMental disorderNeuronal antibodiesPsychiatric symptom scoresSchizophrenia

Identifiers

PMID34473324
OpenAlexW3197680876

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.