Evidence map›Paper›PMID 34473287›Full record

ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2023

Climate change and nephrology.

Fumihiko Sasai, Carlos Roncal-Jimenez, Keegan Rogers, Yuka Sato, Jared M Brown, Jason Glaser, Gabriela Garcia, Laura Gabriela Sanchez-Lozada, Bernardo Rodriguez-Iturbe, Jaime Butler Dawson and 6 more

Open access · greenAbstract read
In one paragraph

Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.

  1. Pooled it
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  18. Chronic kidney disease.Nature reviews. Disease primers · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 5 countries.

Fumihiko SasaiDivision of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Carlos Roncal-JimenezDivision of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Keegan RogersDepartment of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Yuka SatoDepartment of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Jared M BrownDepartment of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Jason GlaserLa Isla Network, Léon, Nicaragua.
Gabriela GarciaDivision of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Laura Gabriela Sanchez-LozadaLaboratory of Renal Physiopathology, Instituto Nacional de Cardiologia, Ignacio Chavez, Mexico City.
Bernardo Rodriguez-IturbeLaboratory of Renal Physiopathology, Instituto Nacional de Cardiologia, Ignacio Chavez, Mexico City.
Jaime Butler DawsonCenter for Health, Work and Environment, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Cecilia SorensenCenter for Health, Work and Environment, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Ana Andres HernandoDivision of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Marvin Gonzalez-QuirozResearch Centre on Health, Work and Environment (CISTA), National Autonomous University of Nicaragua, León, Nicaragua.
Miguel LanaspaDivision of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Lee S NewmanCenter for Health, Work and Environment, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Richard J JohnsonDivision of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
University of Colorado Anschutz Medical Campus · USColorado School of Public Health · USUniversidad Nacional Autónoma de Nicaragua-León · NIInstituto Nacional de Cardiología · MXInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán · MXNagoya University · JP

Funding

Silica Nephropathy and Chronic Kidney Disease of Unknown EtiologyR01DK125351 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Jared Michael Brown, LEE S NEWMAN · 2020 to 2026
$4.0M
La Isla NetworkNIDDK NIH HHS R01 DK125351NIH HHS DK125351
6 · The paper itself

Abstract

Climate change should be of special concern for the nephrologist, as the kidney has a critical role in protecting the host from dehydration, but it is also a favorite target of heat stress and dehydration. Here we discuss how rising temperatures and extreme heat events may affect the kidney. The most severe presentation of heat stress is heat stroke, which can result in severe electrolyte disturbance and both acute and chronic kidney disease (CKD). However, lesser levels of heat stress also have multiple effects, including exacerbating kidney disease and precipitating cardiovascular events in subjects with established kidney disease. Heat stress can also increase the risk for kidney stones, cause multiple electrolyte abnormalities and induce both acute and chronic kidney disease. Recently there have been multiple epidemics of CKD of uncertain etiology in various regions of the world, including Mesoamerica, Sri Lanka, India and Thailand. There is increasing evidence that climate change and heat stress may play a contributory role in these conditions, although other causes, including toxins, could also be involved. As climate change worsens, the nephrologist should prepare for an increase in diseases associated with heat stress and dehydration.

Indexed as

Heat Stress DisordersNephrologyRenal Insufficiency, ChronicClimate ChangeDehydrationHumansKidneyCKD of non-traditional causeCKD of uncertain etiologyCKD of unknown etiologydehydrationglobal warmingheat stressheat strokeMesoamerican nephropathynephrolithiasisSri Lankan nephropathy

Identifiers

PMID34473287
PMCPMC9869860
OpenAlexW3198221850

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.