Evidence map›Paper›PMID 34473090›Full record

ArticleActa crystallographica. Section D, Structural biology2021

Structural and functional analysis of the C-terminal region of Streptococcus gordonii SspB.

Norbert Schormann, Sangeetha Purushotham, Joshua L Mieher, Manisha Patel, Hui Wu, Champion Deivanayagam

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta crystallographica. Section D, Structural biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Norbert SchormannDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0003-4215-7017
Sangeetha PurushothamDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Joshua L MieherDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Manisha PatelDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Hui WuDepartment of Integrative Biomedical and Diagnostic Sciences, Oregon Health and Science University School of Dentistry, Portland, OR 97239, USA.
Champion DeivanayagamDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0003-2972-1824

Funding

Dental Academic Research Training Program (DART)T90DE022736 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Amjad Javed · 2012 to 2026
$6.7M
Glycosylation & Function of an Oral Streptococcal AdhesinR01DE017954 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WU, HUI · 2007 to 2022
$5.8M
SMALL MOLECULE INHIBITORS OF CARIOGENIC BIOFILMSR01DE022350 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Christian Corey Melander, Hui Wu · 2012 to 2026
$4.3M
The Structural and Functional Determination of Streptococcus mutans AdherenceR01DE029007 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DEIVANAYAGAM, CHAMPION CHRISTDOSS SELVAKUMAR, WU, HUI · 2020 to 2024
$2.1M
PORT (Portland Oral health Research Training)R90DE031533 · NIDCR · OREGON HEALTH & SCIENCE UNIVERSITY · PI WU, HUI · 2021 to 2025
$821k
National Institutes of Health, National Institute of Dental and Craniofacial Research T90-DE022736NIDCR NIH HHS R01 DE017954NIDCR NIH HHS R01 DE022350NIDCR NIH HHS R01 DE029007NIDCR NIH HHS R90 DE031533NIDCR NIH HHS T90 DE022736
6 · The paper itself

Abstract

Streptococcus gordonii is a member of the viridans streptococci and is an early colonizer of the tooth surface. Adherence to the tooth surface is enabled by proteins present on the S. gordonii cell surface, among which SspB belongs to one of the most well studied cell-wall-anchored adhesin families: the antigen I/II (AgI/II) family. The C-terminal region of SspB consists of three tandemly connected individual domains that display the DEv-IgG fold. These C-terminal domains contain a conserved Ca

Indexed as

Adhesins, BacterialAmino Acid SequenceBacterial ProteinsBinding SitesHumansStreptococcal InfectionsStreptococcus gordoniiStreptococcus mutansStructure-Activity RelationshipAdhesins, BacterialBacterial Proteinssalivary agglutinin receptor, StreptocococcusadhesinsC123 domainsDev-IgG foldGp340SAGsalivary agglutininSspBStreptococcus gordonii

Identifiers

PMID34473090
PMCPMC8411976

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.