Evidence map›Paper›PMID 34473011›Full record

ArticleJournal of the American Nutrition Association

Examination of the Moderating Effect of Race on the Relationship between Vitamin D Status and COVID-19 Test Positivity Using Propensity Score Methods.

Ian Crandell, Michelle Rockwell, Phyllis Whitehead, Kimberly Ferren Carter, Alexandra Hanlon

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Nutrition Association. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Vitamin D and COVID-19-Revisited.Journal of internal medicine · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ian CrandellCenter for Biostatistics and Health Data Sciences, Virginia Polytechnic Institute and State University, Roanoke, Virginia, USA.
Michelle RockwellFamily and Community Medicine, Carilion Clinic and Virginia Tech Carilion School of Medicine, Roanoke, Virginia, USA.ORCID 0000-0001-7910-6083
Phyllis WhiteheadDepartment of Ethics and Palliative Medicine, Carilion Clinic, Roanoke, Virginia, USA.
Kimberly Ferren CarterDepartment of Nursing Research and Evidence-based practice, Carilion Clinic, Roanoke, Virginia, USA.ORCID 0000-0003-2341-1235
Alexandra HanlonCenter for Biostatistics and Health Data Sciences, Virginia Polytechnic Institute and State University, Roanoke, Virginia, USA.ORCID 0000-0002-9612-2197
Carilion Clinic · USVirginia Tech · US

Funding

The integrated Translational Health Research Institute of Virginia (iTHRIV): Using Data to Improve HealthUL1TR003015 · NCATS · UNIVERSITY OF VIRGINIA · PI BROWN, DONALD E, JOHNSTON, KAREN C. · 2019 to 2023
$20.3M
NCATS NIH HHS UL1 TR003015
6 · The paper itself

Abstract

introductionWith a well-established role in inflammation and immune function, vitamin D status has emerged as a potential factor for coronavirus disease-2019 (COVID-19).

objectiveThe purpose of this study was to evaluate the moderating effect of race on the relationship between vitamin D status and the risk of COVID-19 test positivity, and to compare propensity score (PS) model results to those obtained from classical bivariate and multivariable models, which have primarily comprised the literature to date.

methodsElectronic health record (EHR) data from TriNetX (unmatched n = 21,629; matched n = 16,602) were used to investigate the effect of vitamin D status, as measured by 25-hydroxyvitamin D [25(OH)D], on the odds of experiencing a positive COVID-19 test using multivariable logistic regression models with and without PS methodology.

resultsHaving normal (

conclusionsModels which use weighting and matching methods resulted in smaller estimated effect sizes than models which do not use weighting or matching. These findings suggest a minimal protective effect of vitamin D status on COVID-19 test positivity in White individuals and no protective effect in Black individuals.

Indexed as

COVID-19Vitamin D DeficiencyHumansPropensity ScoreVitamin DVitaminsVitamin DVitamins25-hydroxyvitamin DCoronaviruslogistic regressionmatchingweighting

Identifiers

PMID34473011
PMCPMC9338428
OpenAlexW3196757828

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.