ReviewChemPlusChem2021
New-Generation Ligand Design for the Gold-Catalyzed Asymmetric Activation of Alkynes.
Review in ChemPlusChem, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Synthesis of 2-Oxazolines fromMolecules (Basel, Switzerland) · 2025Review
- Synergistic Gold-Silicon Catalysis: Unravelling Alkynyl Gold Reactivity and Application to the High-Performance C-Alkynylation of Glycals.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Gold(I)-Catalyzed Enantioselective Ring Expansions of Allenyl Cyclopropanols and Cyclobutanols.Organic letters · 2025Article
- Bifunctional Chiral ImPy-Carbene Ligands. H-Bonding Controlled Reactivity and Enantioselectivity in Au(I)-Catalysis.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Practical Synthesis of Chiral Ferrocenenylphosphino-Gold(I) Catalysts and NEST Analysis of the Enantioinduction.ACS catalysis · 2025Article
- Gold-catalyzed highly enantioselective cycloadditions of 1,6-enynes and 1,6-diynes assisted by remote hydrogen bonding interaction.iScience · 2024Article
- Zinc-Catalyzed Cyclization of Alkynyl Derivatives: Substrate Scope and Mechanistic Insights.Inorganic chemistry · 2024Article
- Gold-Catalyzed Homo/Heterodimerization of Terminal Alkynes Facilitated by Metal-Ligand Cooperation.Organic letters · 2024Article
- Chiral Bifunctional Phosphine Ligand Enables Asymmetric Trapping of Catalytic Vinyl Gold Carbene Species.Journal of the American Chemical Society · 2024Article
- Hydrogen-Bonded Matched Ion Pair Gold(I) Catalysis.ACS catalysis · 2023Article
- Gold-Catalyzed Amine Cascade Addition to Diyne-Ene: Enantioselective Synthesis of 1,2-Dihydropyridines.Angewandte Chemie (International ed. in English) · 2023Article
- H-Bonded Counterion-Directed Catalysis: Enantioselective Gold(I)-Catalyzed Addition to 2-Alkynyl Enones as a Case Study.European journal of organic chemistry · 2022Article
- Chiral Hemilabile P,N-Ligand-Assisted Gold Redox Catalysis for Enantioselective Alkene Aminoarylation.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Boosting Gold(I) Catalysis via Weak Interactions: New Fine-Tunable Impy Ligands.ACS organic & inorganic Au · 2022Article
- Optical resolution of 1,16-dihydroxytetraphenylene by chiral gold(iii) complexation and its applications as chiral ligands in asymmetric catalysis.Chemical science · 2022Article
- Stereoisomeric Tris-BINOL-Menthol Bulky Monophosphites: Synthesis, Characterisation and Application in Rhodium-Catalysed Hydroformylation.Molecules (Basel, Switzerland) · 2022Article
- Planar Chiral 1,3-Disubstituted Ferrocenyl Phosphine Gold(I) Catalysts.ACS catalysis · 2022Article
- H-Bonded Counterion-Directed Enantioselective Au(I) Catalysis.Journal of the American Chemical Society · 2022Article
- Gold-Catalyzed Reaction of Propargyl Esters and Alkynylsilanes: Synthesis of Vinylallene Derivatives through a Twofold 1,2-Rearrangement.Angewandte Chemie (International ed. in English) · 2021Article
- New-Generation Ligand Design for the Gold-Catalyzed Asymmetric Activation of Alkynes.ChemPlusChem · 2021Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Gold(I) catalysts are ideal for the activation of alkynes under very mild conditions. However, unlike allenes or alkenes, the triple bond of alkynes cannot be prochiral. In addition, the linear coordination displayed by gold(I) complexes places the chiral ligand far away from the substrate resulting in an inefficient transfer of chiral information. This poses a significant challenge for the achievement of high enantiocontrol in gold(I)-catalyzed reactions of alkynes. Although considerable progress on enantioselective gold(I)-catalyzed transformations has recently been achieved, the asymmetric activation of non-prochiral alkyne-containing small molecules still represents a great challenge. Herein we summarize recent advances in intra- and intermolecular enantioselective gold(I)-catalyzed reactions involving alkynes, discussing new chiral ligand designs that lie at the basis of these developments. We also focus on the mode of action of these catalysts, their possible limitations towards a next-generation of more efficient ligand designs. Finally, square planar chiral gold(III) complexes, which offer an alternative to chiral gold(I) complexes, are also discussed.
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Registered trials
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