ArticleDiabetes, obesity & metabolism2021
Associations of weight loss with obesity-related comorbidities in a large integrated health system.
Article in Diabetes, obesity & metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed.
- Analysis of Tirzepatide Acquisition Costs and Weight Reduction Outcomes in the United Kingdom: Insights from the SURMOUNT-1 Study.Advances in therapy · 2025Trial
- Trial
- Change in body mass index and disease burden among people with obesity and multiple long-term conditions.Diabetes, obesity & metabolism · 2026Article
- Real-World Weight Loss Is Associated With a Reduction in Cancer Risk.Obesity (Silver Spring, Md.) · 2026Observational
- Article
- Nutrition and health canteen-based lifestyle intervention: association with weight management, lipid metabolism regulation, and inflammation alleviation in middle-aged adults.Frontiers in nutrition · 2026Article
- Paraesophageal hernia repair combined with Roux-en-Y gastric bypass reduces short-term hernia recurrence with added metabolic benefit in patients with BMI ≥ 35: A 15-year experience.Surgical endoscopy · 2025Article
- Sex differences in the associations between prior weight loss and all-cause or cardiovascular mortality in non-elderly individuals with hyperuricemia: a mortality follow-up study.Nutrition & metabolism · 2025Article
- Evaluation of clinical benefits and economic value of weight loss in a Swedish population using a simulation model.Obesity (Silver Spring, Md.) · 2025Article
- Assessment of the Potential Clinical and Economic Impact of Weight Loss in the Adult Population with Obesity and Associated Comorbidities in Spain.Advances in therapy · 2025Article
- Clinical Data Mega-Collection of Obesity and Obesity-Related Trials: Primary Inclusion Criteria from All Studies and Highlights of Clinical Efficacy Analysis of GLP-1 Drugs.Journal of clinical medicine · 2025Article
- Population-level impact of weight loss on predicted healthcare spending and the incidence of obesity-related outcomes in the Asia-Pacific region: a modelling study.BMC global and public health · 2024Article
- An interpretable predictive deep learning platform for pediatric metabolic diseases.Journal of the American Medical Informatics Association : JAMIA · 2024Article
- Cost-effectiveness of semaglutide 2.4 mg in chronic weight management in Portugal.Diabetology & metabolic syndrome · 2024Article
- How to establish an endoscopic bariatric practice.World journal of gastrointestinal endoscopy · 2024Article
- Effect of a Low-Carbohydrate Diet With or Without Exercise on Anxiety and Eating Behavior and Associated Changes in Cardiometabolic Health in Overweight Young Women.Frontiers in nutrition · 2022Article
- Editorial: Interaction effect of low carbohydrate diets and exercise on weight loss and cardio-metabolic health.Frontiers in nutrition · 2022Article
- Associations of weight loss with obesity-related comorbidities in a large integrated health system.Diabetes, obesity & metabolism · 2021Article
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo determine the health outcomes associated with weight loss in individuals with obesity, and to better understand the relationship between disease burden (disease burden; ie, prior comorbidities, healthcare utilization) and weight loss in individuals with obesity by analysing electronic health records (EHRs). MATERIALS AND
methodsWe conducted a case-control study using deidentified EHR-derived information from 204 921 patients seen at the Cleveland Clinic between 2000 and 2018. Patients were aged ≥20 years with body mass index ≥30 kg/m
resultsWeight loss was associated with reduced incidence of many outcomes (eg, type 2 diabetes, nonalcoholic steatohepatitis/nonalcoholic fatty liver disease, obstructive sleep apnoea, hypertension; P < 0.05). Weight loss >10% was associated with increased incidence of certain outcomes including stroke and substance abuse. However, many outcomes that increased with weight loss were attenuated by disease burden adjustments.
conclusionsThis study provides the most comprehensive real-world evaluation of the health impacts of weight change to date. After comorbidity burden and healthcare utilization adjustments, weight loss was associated with an overall reduction in risk of many adverse outcomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.