Evidence map›Paper›PMID 34472616›Full record

ArticleJournal of the American Medical Informatics Association : JAMIA2022

Operationalizing and analyzing 2-step gender identity questions: Methodological and ethical considerations.

Kacie M Kidd, Gina M Sequeira, Scott D Rothenberger, Taylor Paglisotti, Alfgeir Kristjansson, Kelsey Schweiberger, Elizabeth Miller, Robert W S Coulter

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Medical Informatics Association : JAMIA, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Protective Factors Against Violence and Substance Use in Adolescents: A Latent Class Analysis.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2026
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  14. Social Support for Rural Gender Diverse Youth Compared to Cisgender Peers.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Kacie M KiddDepartment of Pediatrics, West Virginia University School of Medicine, Morgantown, West Virginia, USA.ORCID 0000-0001-7796-2230
Gina M SequeiraDepartment of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, Washington, USA.
Scott D RothenbergerDepartment of Internal Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Taylor PaglisottiHarvard University T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Alfgeir KristjanssonDepartment of Social and Behavioral Sciences, West Virginia University School of Public Health, Morgantown, West Virginia, USA.
Kelsey SchweibergerDepartment of Pediatrics, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Elizabeth MillerDepartment of Pediatrics, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Robert W S CoulterDepartment of Behavioral and Community Health Sciences, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, USA.
University of Pittsburgh · USWest Virginia University · USHarvard University · USSeattle Children's Hospital · US

Funding

NRSA Training CoreTL1TR001858 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RADOMSKI, THOMAS, RUBIO, DORIS M · 2016 to 2025
$11.1M
Developing and Piloting a School Staff-Based Intervention to Reduce Alcohol and Drug Use Among Sexual Minority YouthK01AA027564 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI COULTER, ROBERT W.S. · 2019 to 2023
$744k
NCATS NIH HHS TL1 TR001858NCATS NIH HHS TL1TRR1858NIAAA NIH HHS K01 AA027564NIAAA NIH HHS K01AA027564
6 · The paper itself

Abstract

objectiveTwo-step questions to assess gender identity are recommended for optimizing care delivery for gender-diverse individuals. As gender identity fields are increasingly integrated into electronic health records, guidance is needed on how to analyze these data. The goal of this study was to assess potential approaches for analyzing 2-step gender identity questions and the impact of each on suicidal ideation. MATERIALS AND

methodsA regional Youth Risk Behavior Survey in one Northeastern school district used a 2-step question to assess gender identity. Three gender measurement strategies (GMSs) were used to operationalize gender identity, (1) combining all gender-diverse youth (GDY) into one category, (2) grouping GDY based on sex assigned at birth, and (3) categorizing GDY based on binary and nonbinary identities. Mixed-effects logistic regression was used to compare odds of suicidal ideation between gender identity categories for each GMS.

resultsOf the 3010 participants, 8.3% were GDY. Subcategories of GDY had significantly higher odds (odds ratio range, 1.6-2.9) of suicidal ideation than cisgender girls regardless of GMS, while every category of GDY had significantly higher odds (odds ratio range, 2.1-5.0) of suicidal ideation than cisgender boys.

conclusionsThe field of clinical informatics has an opportunity to incorporate inclusive items like the 2-step gender identity question into electronic health records to optimize care and strengthen clinical research. Analysis of the 2-step gender identity question impacts study results and interpretation. Attention to how data about GDY are captured will support for more nuanced, tailored analyses that better reflect unique experiences within this population.

Indexed as

Gender IdentityTransgender PersonsAdolescentChildFemaleHumansMaleOdds RatioSchoolsSuicidal Ideationadolescentgender identityinformaticssuicidal ideationstransgender persons

Identifiers

PMID34472616
PMCPMC8757306
OpenAlexW3198057722

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.