Evidence map›Paper›PMID 34472498›Full record

ArticleMedical gas research

Effect of an ionic antineoplastic agent Cytoreg on blood chemistry in a Wistar rat model.

Katiusca Villasana, William Quintero, Yepsys Montero, Cristian Pino, Oscar Uzcategui, Geizon Torres, Mariangel Prada, Lewis Pozo, William Bauta, William Jimenez

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical gas research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Katiusca VillasanaBiochemistry Laboratories, Department of Pathology, University of the Andes, Mérida, Venezuela.
William QuinteroDepartment of Biology, Faculty of Science, University of the Andes, Mérida, Venezuela.
Yepsys MonteroVivarium, University of the Andes, Mérida, Venezuela.
Cristian PinoDepartment of Technical and Experimental Surgery, Faculty of Medicine, University of the Andes, Mérida, Venezuela.
Oscar UzcateguiDepartment of Technical and Experimental Surgery, Faculty of Medicine, University of the Andes, Mérida, Venezuela.
Geizon TorresVitalis, Clinical Laboratory, Smart Health Laboratory, Merida, Venezuela.
Mariangel PradaVitalis, Clinical Laboratory, Smart Health Laboratory, Merida, Venezuela.
Lewis PozoCytorex de Venezuela SA, Maracaibo, Venezuela.
William BautaCytorex Biosciences, Inc., Weston, FL, USA.
William JimenezCytorex Biosciences, Inc., Weston, FL, USA.
University of the Andes · VE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytoreg is an ionic therapeutic agent comprising a mixture of hydrochloric, sulfuric, phosphoric, hydrofluoric, oxalic, and citric acids. In diluted form, it has demonstrated efficacy against human cancers in vitro and in vivo. Although Cytoreg is well tolerated in mice, rats, rabbits, and dogs by oral and intravenous administration, its mechanism of action is not documented. The acidic nature of Cytoreg could potentially disrupt the pH and levels of ions and dissolved gases in the blood. Here, we report the effects of the intravenous administration of Cytoreg on the arterial pH, oxygen and carbon dioxide pressures, and bicarbonate, sodium, potassium, and chloride concentrations. Our results demonstrate that Cytoreg does not disturb the normal blood pH, ion levels, or carbon dioxide content, but increases oxygen levels in rats. These data are consistent with the excellent tolerability of intravenous Cytoreg observed in rabbits, and dogs. The study was approved by the Bioethics Committee of the University of the Andes, Venezuela (CEBIOULA) (approval No. 125) on November 3, 2019.

Indexed as

Acid-Base EquilibriumAntineoplastic AgentsAnimalsBicarbonatesDogsHydrogen-Ion ConcentrationMiceRabbitsRatsRats, WistarAntineoplastic AgentsBicarbonatesacid-base homeostasisarterial blood chemistryCytorexelectrolyte balanceion therapyoxygen pressuretissue oxygenationWarburg effect

Identifiers

PMID34472498
PMCPMC8447950
OpenAlexW3197921582

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.