Evidence map›Paper›PMID 34472457›Full record

ReviewNeural regeneration research2022

Functional and immunological peculiarities of peripheral nerve allografts.

Kelly C S Roballo, Jason P Gigley, Tyler A Smith, George D Bittner, Jared S Bushman

Abstract readReview
In one paragraph

Review in Neural regeneration research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Review
  3. Nerve tissue model on a micropatterned surface: Axon guidance and neural regeneration.Journal of materials science. Materials in medicine · 2025
    Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Nerve-on-a-Chip Derived Biomimicking Microfibers for Peripheral Nerve Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  9. Article
  10. ComprehensiveFrontiers in bioengineering and biotechnology · 2023
    Article
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kelly C S RoballoSchool of Pharmacy, University of Wyoming, Laramie, WY, USA.
Jason P GigleyDepartment of Molecular Biology, University of Wyoming, Laramie, WY, USA.
Tyler A SmithDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA.
George D BittnerDepartment of Neuroscience, University of Texas at Austin, Austin, TX, USA.
Jared S BushmanSchool of Pharmacy, University of Wyoming, Laramie, WY, USA.

Funding

Wyoming INBRE Phase 4- Equipment Supplement for x-ray diffractometer for Center for Advanced Scientific InstrumentationP20GM103432 · NIGMS · UNIVERSITY OF WYOMING · PI Nicolas A. Blouin · 2012 to 2026
$56.8M
Zebrafish Models of CNS Injury and Locomotor RecoveryP20GM121310 · NIGMS · UNIVERSITY OF WYOMING · PI Qian-Quan Sun · 2017 to 2026
$27.2M
A novel bioengineered technique to rapidly and permanently repair cut PNS nervesR01NS081063 · NINDS · UNIVERSITY OF TEXAS AT AUSTIN · PI BITTNER, GEORGE DAVIS · 2012 to 2016
$1.7M
NIGMS NIH HHS P20 GM103432NIGMS NIH HHS P20 GM121310NINDS NIH HHS R01 NS081063
6 · The paper itself

Abstract

This review addresses the accumulating evidence that live (not decellularized) allogeneic peripheral nerves are functionally and immunologically peculiar in comparison with many other transplanted allogeneic tissues. This is relevant because live peripheral nerve allografts are very effective at promoting recovery after segmental peripheral nerve injury via axonal regeneration and axon fusion. Understanding the immunological peculiarities of peripheral nerve allografts may also be of interest to the field of transplantation in general. Three topics are addressed: The first discusses peripheral nerve injury and the potential utility of peripheral nerve allografts for bridging segmental peripheral nerve defects via axon fusion and axon regeneration. The second reviews evidence that peripheral nerve allografts elicit a more gradual and less severe host immune response allowing for prolonged survival and function of allogeneic peripheral nerve cells and structures. Lastly, potential mechanisms that may account for the immunological differences of peripheral nerve allografts are discussed.

Indexed as

allograftanimal modelimmunologyneuroimmunologyperipheral nerve injuryregenerationrepairtissue regenerationtissue transplantationtransplant

Identifiers

PMID34472457
PMCPMC8530136

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.