Evidence map›Paper›PMID 34472454›Full record

ReviewNeural regeneration research2022

Towards a comprehensive understanding of p75 neurotrophin receptor functions and interactions in the brain.

Joel F Ritala, Seán B Lyne, Antti Sajanti, Romuald Girard, Janne Koskimäki

Open access · goldAbstract readReview
In one paragraph

Review in Neural regeneration research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Beyond Traditional Use: The Scientific Evidence for the Role ofPharmaceuticals (Basel, Switzerland) · 2025
    Review
  2. Small-Molecule Trk Agonists: Where Do We Go from Here?Journal of medicinal chemistry · 2025
    Review
  3. Selective Modulation of Trk Receptors byACS chemical neuroscience · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Joel F RitalaDivision of Clinical Neurosciences, Department of Neurosurgery, Turku University Hospital and University of Turku, Turku, Finland.
Seán B LyneNeurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine and Biological Sciences, Chicago, IL, USA.
Antti SajantiDivision of Clinical Neurosciences, Department of Neurosurgery, Turku University Hospital and University of Turku, Turku, Finland.
Romuald GirardNeurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine and Biological Sciences, Chicago, IL, USA.
Janne KoskimäkiDivision of Clinical Neurosciences, Department of Neurosurgery, Turku University Hospital and University of Turku, Turku; Department of Psychiatry, Central Hospital of Southern Ostrobothnia, Seinäjoki; Neuroscience Center, HiLIFE, University of Helsinki, Helsinki, Finland.
Turku University Hospital · FIUniversity of Chicago · USUniversity of Turku · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of neurotrophins in neuronal plasticity has recently become a strong focus in neuroregeneration research field to elucidate the biological mechanisms by which these molecules modulate synapses, modify the response to injury, and alter the adaptation response. Intriguingly, the prior studies highlight the role of p75 neurotrophin receptor (p75

Indexed as

bioinformaticsbrain injurydata miningneuronneurotrophinsp75NTRplasticityregeneration

Identifiers

PMID34472454
PMCPMC8530109
OpenAlexW3198676374

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.