Evidence map›Paper›PMID 34472453›Full record

ReviewAsian journal of andrology

The role of retinoic acid in the commitment to meiosis.

Rachel L Gewiss, M Christine Schleif, Michael D Griswold

Open access · goldAbstract readReview
In one paragraph

Review in Asian journal of andrology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Generation of Stra8-Cre/ERT2 Mouse Activator Strain for Inducible Cre-lox Recombination in Spermatocytes.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2026
    Article
  6. Review
  7. Proteome of the testicular cell-conditioned medium supports germ cell differentiationJournal of advanced veterinary and animal research · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Low-polarity untargeted metabolomic profiling as a tool to gain insight into seminal fluid.Metabolomics : Official journal of the Metabolomic Society · 2023
    Article
  17. Article
  18. Article
  19. Article
  20. Frontiers in cell and developmental biology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Rachel L GewissSchool of Molecular Biosciences and Center for Reproductive Biology, Washington State University, Pullman, WA 99164, USA.
M Christine SchleifSchool of Molecular Biosciences and Center for Reproductive Biology, Washington State University, Pullman, WA 99164, USA.
Michael D GriswoldSchool of Molecular Biosciences and Center for Reproductive Biology, Washington State University, Pullman, WA 99164, USA.
Washington State University · US

Funding

Hormonal Regulation Sertoli Cell MaturationR01HD010808 · NICHD · WASHINGTON STATE UNIVERSITY · PI MICHAEL D GRISWOLD · 1985 to 2026
$6.0M
NICHD NIH HHS R01 HD010808
6 · The paper itself

Abstract

Male meiosis is a complex process whereby spermatocytes undergo cell division to form haploid cells. This review focuses on the role of retinoic acid (RA) in meiosis, as well as several processes regulated by RA before cell entry into meiosis that are critical for proper meiotic entry and completion. Here, we discuss RA metabolism in the testis as well as the roles of stimulated by retinoic acid gene 8 (STRA8) and MEIOSIN, which are responsive to RA and are critical for meiosis. We assert that transcriptional regulation in the spermatogonia is critical for successful meiosis.

Indexed as

AnimalsCell DifferentiationHumansMeiosisSpermatogenesisTretinoinTretinoinmeiosisretinoic acidspermatogenesistestis

Identifiers

PMID34472453
PMCPMC8577254
OpenAlexW3198740981

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.