Evidence map›Paper›PMID 34472363›Full record

ArticleJournal of the American Heart Association2021

Acute Genetic Ablation of Cardiac Sodium/Calcium Exchange in Adult Mice: Implications for Cardiomyocyte Calcium Regulation, Cardioprotection, and Arrhythmia.

Sabine Lotteau, Rui Zhang, Adina Hazan, Christina Grabar, Devina Gonzalez, Stephan Aynaszyan, Kenneth D Philipson, Michela Ottolia, Joshua I Goldhaber

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Regulation of Na/Ca exchange by cytoplasmic protons modifies intracellular calcium dynamics and the cardiac response to ischemia.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Immune cells and arrhythmias.Cardiovascular research · 2025
    Review
  7. An In Vivo Model of Estrogen Supplementation Concerning the Expression of CaJournal of cardiovascular development and disease · 2024
    Article
  8. Article
  9. Article
  10. Mechanisms of spontaneous CaThe Journal of physiology · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Sabine LotteauSmidt Heart Institute Cedars-Sinai Medical Center Los Angeles CA.ORCID 0000-0002-6087-0521
Rui ZhangSmidt Heart Institute Cedars-Sinai Medical Center Los Angeles CA.
Adina HazanSmidt Heart Institute Cedars-Sinai Medical Center Los Angeles CA.
Christina GrabarSmidt Heart Institute Cedars-Sinai Medical Center Los Angeles CA.
Devina GonzalezSmidt Heart Institute Cedars-Sinai Medical Center Los Angeles CA.ORCID 0000-0002-8222-570X
Stephan AynaszyanSmidt Heart Institute Cedars-Sinai Medical Center Los Angeles CA.
Kenneth D PhilipsonDepartment of Physiology David Geffen School of Medicine at UCLA Los Angeles CA.
Michela OttoliaDivision of Molecular Medicine Department of Anesthesiology and Perioperative Medicine David Geffen School of Medicine at UCLA Los Angeles CA.
Joshua I GoldhaberSmidt Heart Institute Cedars-Sinai Medical Center Los Angeles CA.ORCID 0000-0001-8413-5719
Cedars-Sinai Medical Center · USUniversity of California, Los Angeles · US

Funding

Training in Advanced Heart Disease ResearchT32HL116273 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI Joshua I Goldhaber, EDUARDO MARBAN · 2013 to 2026
$5.6M
Molecular Biology of Cardiac Sodium-Calcium ExchangeR01HL048509 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GOLDHABER, JOSHUA I, PHILIPSON, KENNETH · 2002 to 2016
$4.7M
Regulation of cellular calcium by cardiac sodium-calcium exchangeR01HL147569 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI GOLDHABER, JOSHUA I, OTTOLIA, MICHELA · 2019 to 2022
$2.6M
Sodium Dependent Inactivation of the Na+-Ca2+ exchange: Relevance to Cardiac FunctionR01HL152296 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI OLCESE, RICCARDO, OTTOLIA, MICHELA · 2021 to 2024
$2.2M
NHLBI NIH HHS R01 HL048509NHLBI NIH HHS R01 HL147569NHLBI NIH HHS R01 HL152296NHLBI NIH HHS T32 HL116273
6 · The paper itself

Abstract

Background Sodium-calcium (Ca

Indexed as

Arrhythmias, CardiacCalciumMyocytes, CardiacReperfusion InjurySodium-Calcium ExchangerAnimalsFibrosisHypertrophyMiceMice, KnockoutMyocardial ContractionTamoxifenCalciumNCX1 protein, mouseSodium-Calcium ExchangerTamoxifenarrhythmiacalcium transientsexcitation‐contraction couplingischemia/reperfusionknock out micesodium‐calcium exchange

Identifiers

PMID34472363
PMCPMC8649274
OpenAlexW3198854126

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.