ArticlePituitary2022
Safety of endoscopic endonasal biopsy for the pituitary stalk-hypothalamic lesions.
Article in Pituitary, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.
- Pituitary stalk biopsy - A systematic review of the safety and efficacy of stalk lesion biopsy.Pituitary · 2026Pooled it
- Pituitary Stalk Lesion Sampling by Transsphenoidal Posterior Lobe Biopsy: A Case Series.Journal of neurological surgery. Part B, Skull base · 2026Article
- Cutaneous Limited Langerhans Cell Histiocytosis Complicated by Late-onset Panhypopituitarism.JCEM case reports · 2025Article
- Mimickers of pituitary tumors.Neuro-oncology advances · 2025Article
- Approach to the Patient: From Endocrinopathy to the Diagnosis of a Histiocytic Disorder.The Journal of clinical endocrinology and metabolism · 2025Review
- The role of surgery for optic pathway gliomas in the era of precision medicine.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Review
- Serum copeptin levels at day two after pituitary surgery and ratio to baseline predict postoperative central diabetes insipidus.Pituitary · 2022Observational
- Pilot Findings on SARS-CoV-2 Vaccine-Induced Pituitary Diseases: A Mini Review from Diagnosis to Pathophysiology.Vaccines · 2022Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
purposeThe indications for and the optimal biopsy approach in pituitary stalk-hypothalamic (PsH) lesions are controversial. Biopsies through an endoscopic endonasal approach (EEA) for PsH lesions have often been considered to cause the infundibulo-tuberal syndrome. The purpose of this study was to analyze the surgical and endocrinological safety of EEA biopsies for PsH lesions.
methodsA total of 39 consecutive patients who underwent an EEA biopsy between June 2011 and August 2020 in a single institute were retrospectively analyzed. The ophthalmological and endocrinological outcomes were assessed before and after surgery.
resultsPsH lesions were confirmed to be diverse pathological diagnoses, ranging from lymphocytic hypophysitis to diffuse midline glioma, and the most common pathologic diagnosis was a germinoma (18 patients, 46.2%). No patients developed visual deterioration after the biopsy. In patients without preoperative panhypopituitarism, 13 out of 28 patients (46.4%) developed new anterior pituitary hormonal deficiencies after the biopsy. When the tissue was collected from the stalk, the endocrinological deterioration rate was 100% (6 of 6 patients), while the rate was 31.8% (7 of 22 patients) when tissue could be harvested from an extra-stalk lesion. The rate of newly developed permanent diabetes insipidus after surgery was 40.9% (9 of 22 patients). The median surgery time was 125 min, and there was no postoperative CSF leakage or infections noted.
conclusionsAn EEA biopsy for PsH lesions is a safe and efficient surgical method unless the tissue is collected from the stalk.
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