ArticleSocial cognitive and affective neuroscience2023
Morphology of the prefrontal cortex predicts body composition in early adolescence: cognitive mediators and environmental moderators in the ABCD Study.
Article in Social cognitive and affective neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Structural and Functional Brain Changes in Children and Adolescents With Obesity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Review
- Delay discounting and nucleus accumbens functional connectivity are related to weight status in adolescents from the ABCD study.Pediatric obesity · 2025Article
- Physical and mental health in adolescence: novel insights from a transdiagnostic examination of FitBit data in the ABCD study.Translational psychiatry · 2024Article
- FTO variation and early frontostriatal brain development in children.Obesity (Silver Spring, Md.) · 2024Article
- Relating neighborhood deprivation to childhood obesity in the ABCD study: Evidence for theories of neuroinflammation and neuronal stress.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2023Article
- Associations among prenatal exposure to gestational diabetes mellitus, brain structure, and child adiposity markers.Obesity (Silver Spring, Md.) · 2023Article
- Physical and Mental Health in Adolescence: Novel Insights from a transdiagnostic examination of FitBit data in the ABCD Study.Research square · 2023Article
- Is there a role for higher cognitive processes in the development of obesity in humans?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Mediating role of obesity on the association between disadvantaged neighborhoods and intracortical myelination.Research square · 2023Article
- Bidirectional Associations Between Adiposity and Cognitive Function: A Prospective Analysis of the Canadian Longitudinal Study on Aging (CLSA).The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Bidirectional Associations Between Adiposity and Cognitive Function and Mediation by Brain Morphology in the ABCD Study.JAMA network open · 2023Article
- The social neuroscience of eating: an introduction to the special issue.Social cognitive and affective neuroscience · 2023Article
- Access to quality health resources and environmental toxins affect the relationship between brain structure and BMI in a sample of pre and early adolescents.Frontiers in public health · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
Abstract
Morphological features of the lateral prefrontal cortex (PFC) in late childhood and early adolescence may provide important clues as to the developmental etiology of clinical conditions such as obesity. Body composition measurements and structural brain imaging were performed on 11 226 youth at baseline (age 9 or 10 years) and follow-up (age 11 or 12 years). Baseline morphological features of the lateral PFC were examined as predictors of body composition. Findings revealed reliable associations between middle frontal gyrus volume, thickness and surface area and multiple indices of body composition. These findings were consistent across both time points and remained significant after covariate adjustment. Cortical thicknesses of the inferior frontal gyrus and lateral orbitofrontal cortex were also reliable predictors. Morphology effects on body composition were mediated by performance on a non-verbal reasoning task. Modest but reliable moderation effects were observed with respect to environmental self-regulatory demand after controlling for sex, race/ethnicity, income and methodological variables. Overall findings suggest that PFC morphology is a reliable predictor of body composition in early adolescence, as mediated through select cognitive functions and partially moderated by environmental characteristics.
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