Evidence map›Paper›PMID 34471870›Full record

ArticleToxicon: X2021

Mitchel Otieno Okumu, James Mucunu Mbaria, Joseph Kangangi Gikunju, Paul Gichohi Mbuthia, Vincent Odongo Madadi, Francis Okumu Ochola, Mercy Seroney Jepkorir

Abstract read
In one paragraph

Article in Toxicon: X, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. A Bioactive Benzyl Terpene fromMolecules (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Molecular Mediated Angiogenesis and Vasculogenesis Networks.International journal of molecular sciences · 2025
    Article
  4. Article
  5. Review
  6. Assessment of theToxicon: X · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Evaluation ofAntioxidants (Basel, Switzerland) · 2022
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mitchel Otieno OkumuDepartment of Public Health, Pharmacology, and Toxicology, University of Nairobi, Kenya.
James Mucunu MbariaDepartment of Public Health, Pharmacology, and Toxicology, University of Nairobi, Kenya.
Joseph Kangangi GikunjuDepartment of Medical Laboratory Science, Jomo Kenyatta University of Agriculture and Technology, Kenya.
Paul Gichohi MbuthiaDepartment of Veterinary Pathology, Microbiology, and Parasitology, University of Nairobi, Kenya.
Vincent Odongo MadadiDepartment of Chemistry, University of Nairobi, Kenya.
Francis Okumu OcholaDepartment of Pharmacology and Toxicology, Moi University, Kenya.
Mercy Seroney JepkorirCentre for Traditional Medicine and Drug Research, Kenya Medical Research Institute, Kenya.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lethality and cytotoxicity assays of snake venoms and their neutralization by antivenom require many mice for the experiments. Recent developments have prompted researchers to seek alternative strategies that minimize the use of mice in line with Russel and Burch's 3Rs philosophy (Replacement, Reduction, and Refinement).

Indexed as

Artemia salinaLethal concentrationLethal doseMiceNecrosis

Identifiers

PMID34471870
PMCPMC8390515

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.