Evidence map›Paper›PMID 34471865›Full record

ArticleiScience2021

Regulatory T cells enhance Th17 migration in psoriatic arthritis which is reversed by anti-TNF.

Dao X Nguyen, Helen M Baldwin, Amara N Ezeonyeji, Mohammed Rohan Butt, Michael R Ehrenstein

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Frontiers in cellular and infection microbiology · 2025
    Article
  4. From PsO to PsA: the role of TFrontiers in medicine · 2024
    Review
  5. Evaluation of CD4Advanced biomedical research · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Dao X NguyenCentre for Rheumatology, Division of Medicine, University College London, 5 University Street, WC1E 6JF London, UK.
Helen M BaldwinCentre for Rheumatology, Division of Medicine, University College London, 5 University Street, WC1E 6JF London, UK.
Amara N EzeonyejiCentre for Rheumatology, Division of Medicine, University College London, 5 University Street, WC1E 6JF London, UK.
Mohammed Rohan ButtCentre for Rheumatology, Division of Medicine, University College London, 5 University Street, WC1E 6JF London, UK.
Michael R EhrensteinCentre for Rheumatology, Division of Medicine, University College London, 5 University Street, WC1E 6JF London, UK.
University College London · GB

Funding

Versus Arthritis 19823
6 · The paper itself

Abstract

Regulatory T cells (Treg) prevent the migration of effector T cells toward sites of inflammation, thereby limiting disease progression. We investigated this aspect of Treg function using psoriatic arthritis (PsA) as an exemplar of chronic inflammation. Patients with PsA had an increased Th17:Treg ratio which was reversed by anti-tumor necrosis factor (TNF) therapy. Utilizing an

Indexed as

biological sciencesimmune system disorderimmunology

Identifiers

PMID34471865
PMCPMC8387926
OpenAlexW3188629290

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.