Evidence map›Paper›PMID 34471854›Full record

ReviewBioelectricity2020

Novel Electrode Designs for Neurostimulation in Regenerative Medicine: Activation of Stem Cells.

Stephanie N Iwasa, HaoTian H Shi, Sung Hwa Hong, Tianhao Chen, Melissa Marquez-Chin, Christian Iorio-Morin, Suneil K Kalia, Milos R Popovic, Hani E Naguib, Cindi M Morshead

Abstract readReview
In one paragraph

Review in Bioelectricity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Stephanie N IwasaThe KITE Research Institute, Toronto Rehabilitation Institute-University Health Network, Toronto, Canada.
HaoTian H ShiDepartment of Mechanical and Industrial Engineering, University of Toronto, Toronto, Canada.
Sung Hwa HongDepartment of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Canada.
Tianhao ChenInstitute of Biomedical Engineering, University of Toronto, Toronto, Canada.
Melissa Marquez-ChinThe KITE Research Institute, Toronto Rehabilitation Institute-University Health Network, Toronto, Canada.
Christian Iorio-MorinDepartment of Neurosurgery, University Health Network, University of Toronto, Toronto, Canada.
Suneil K KaliaThe KITE Research Institute, Toronto Rehabilitation Institute-University Health Network, Toronto, Canada.
Milos R PopovicThe KITE Research Institute, Toronto Rehabilitation Institute-University Health Network, Toronto, Canada.
Hani E NaguibDepartment of Mechanical and Industrial Engineering, University of Toronto, Toronto, Canada.
Cindi M MorsheadThe KITE Research Institute, Toronto Rehabilitation Institute-University Health Network, Toronto, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neural stem and progenitor cells (i.e., neural precursors) are found within specific regions in the central nervous system and have great regenerative capacity. These cells are electrosensitive and their behavior can be regulated by the presence of electric fields (EFs). Electrical stimulation is currently used to treat neurological disorders in a clinical setting. Herein we propose that electrical stimulation can be used to enhance neural repair by regulating neural precursor cell (NPC) kinetics and promoting their migration to sites of injury or disease. We discuss how intrinsic and extrinsic factors can affect NPC migration in the presence of an EF and how this impacts electrode design with the goal of enhancing tissue regeneration. We conclude with an outlook on future clinical applications of electrical stimulation and highlight technological advances that would greatly support these applications.

Indexed as

cell migrationelectrical stimulationelectrode design

Identifiers

PMID34471854
PMCPMC8370381

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.