Evidence map›Paper›PMID 34471808›Full record

ReviewBioelectricity2019

Ion Channels in Bone Morphogenetic Protein Signaling.

Laura Faith George, Trevor Isner, Emily Anne Bates

Open access · bronzeAbstract readReview
In one paragraph

Review in Bioelectricity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Laura Faith GeorgeDepartment of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado.
Trevor IsnerDepartment of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado.
Emily Anne BatesDepartment of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado.
University of Colorado Denver · US

Funding

Ion channel mediated control of mophogen signaling for craniofacial development in mammalsR01DE025311 · NIDCR · UNIVERSITY OF COLORADO DENVER · PI BATES, EMILY · 2018 to 2023
$1.8M
NIDCR NIH HHS R01 DE025311
6 · The paper itself

Abstract

How a single fertilized egg develops into a complex multicellular organism is one of the great mysteries of life. Developmental biology textbooks describe cascades of ligands, receptors, kinases, and transcription factors that designate proliferation, migration, and ultimately fate of cells organized into a multicellular organism. Recently, it has become apparent that ion channels are integral to the process of developmental signaling. Ion channels provide bioelectric signals that must intersect with the known developmental signaling pathways. We review some evidence that bioelectric signaling contributes to bone morphogenetic protein signaling.

Indexed as

bioelectric signalingBMPbone morphogenetic proteinchannelopathiesinwardly rectifying potassium channelsion channels and pumps

Identifiers

PMID34471808
PMCPMC8370264
OpenAlexW2920801730

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.