Evidence map›Paper›PMID 34471679›Full record

ArticleACS central science2021

Unlocking the Potential of High-Throughput Experimentation for Electrochemistry with a Standardized Microscale Reactor.

Jonas Rein, James R Annand, Michael K Wismer, Jiantao Fu, Juno C Siu, Artis Klapars, Neil A Strotman, Dipannita Kalyani, Dan Lehnherr, Song Lin

Open access · diamondAbstract read
In one paragraph

Article in ACS central science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
9.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 135 citations in OpenAlex.

  1. Review
  2. Mild and efficient coupling reactions enabled byCatalysis science & technology · 2026
    Article
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  9. Considerations in Pursuing Reaction Scope Generality.Angewandte Chemie (International ed. in English) · 2025
    Review
  10. Advancing Organic Chemistry Using High-Throughput Experimentation.Angewandte Chemie (International ed. in English) · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jonas ReinDepartment of Chemistry and Chemical Biology, Cornell University, 162 Sciences Drive, Ithaca, New York 14853, United States.
James R AnnandDepartment of Chemistry and Chemical Biology, Cornell University, 162 Sciences Drive, Ithaca, New York 14853, United States.
Michael K WismerScientific Engineering and Design, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
Jiantao FuDiscovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.ORCID https://orcid.org/0000-0002-1067-6915
Juno C SiuDepartment of Chemistry and Chemical Biology, Cornell University, 162 Sciences Drive, Ithaca, New York 14853, United States.ORCID https://orcid.org/0000-0003-4675-5399
Artis KlaparsProcess Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States.
Neil A StrotmanProcess Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States.ORCID https://orcid.org/0000-0002-5350-8735
Dipannita KalyaniDiscovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
Dan LehnherrProcess Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States.ORCID https://orcid.org/0000-0001-8392-1208
Song LinDepartment of Chemistry and Chemical Biology, Cornell University, 162 Sciences Drive, Ithaca, New York 14853, United States.ORCID https://orcid.org/0000-0002-8880-6476
Merck & Co., Inc., Rahway, NJ, USA (United States) · USCornell University · US

Funding

Electrochemistry as an enabling tool for reaction discoveryR01GM130928 · NIGMS · STANFORD UNIVERSITY · PI Song Lin · 2018 to 2026
$3.4M
NIGMS NIH HHS R01 GM130928
6 · The paper itself

Abstract

Organic electrochemistry has emerged as an enabling and sustainable technology in modern organic synthesis. Despite the recent renaissance of electrosynthesis, the broad adoption of electrochemistry in the synthetic community, and especially in industrial settings, has been hindered by the lack of general, standardized platforms for high-throughput experimentation (HTE). Herein, we disclose the design of the HT

Identifiers

PMID34471679
PMCPMC8393209
OpenAlexW3139355318

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.