Protective Effect of Penetratin Analogue-Tagged SOD1 on Cisplatin-Induced Nephrotoxicity through Inhibiting Oxidative Stress and JNK/p38 MAPK Signaling Pathway.

Xiao-Lu Wang, Liang Wang, Fo-Lan Lin, Si-Si Li, Ting-Xuan Lin, Ren-Wang Jiang

Open access · hybridAbstract read

In one paragraph

Article in Oxidative medicine and cellular longevity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it

0cells of the map it votes in

5citing papers in PubMed

1.5field-weighted citation impact, top 18% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

Tat-GSTpi Inhibits Dopaminergic Cells against MPPBiomedicines · 2023
Article
Cisplatin-Induced Kidney Toxicity: Potential Roles of Major NADBiomolecules · 2022
Review
The Imbalance of Mitochondrial Homeostasis of Peripheral Blood-Derived Macrophages Mediated by MAFLD May Impair the Walking Ability of Elderly Patients with Osteopenia.Oxidative medicine and cellular longevity · 2022
Article
Magnesium Lithospermate B Protects Against Cisplatin-Induced Acute Kidney Injury via Alleviating Mitochondrial Dysfunction.Drug design, development and therapy · 2022
Article
Bibliometric and visual analysis of nephrotoxicity research worldwide.Frontiers in pharmacology · 2022
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Xiao-Lu WangGuangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research and International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education, Jinan University, Guangzhou 510632, China.ORCID https://orcid.org/0000-0001-5749-1152

Liang WangDepartment of Oncology, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China.ORCID https://orcid.org/0000-0002-2262-7803

Fo-Lan LinGuangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research and International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education, Jinan University, Guangzhou 510632, China.ORCID https://orcid.org/0000-0002-4350-7915

Si-Si LiGuangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research and International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education, Jinan University, Guangzhou 510632, China.ORCID https://orcid.org/0000-0002-1373-5992

Ting-Xuan LinGuangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research and International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education, Jinan University, Guangzhou 510632, China.ORCID https://orcid.org/0000-0002-7274-4100

Ren-Wang JiangGuangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research and International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education, Jinan University, Guangzhou 510632, China.ORCID https://orcid.org/0000-0002-0730-9866

Jinan University · CNFirst Affiliated Hospital of Jinan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Copper/zinc superoxide dismutase (SOD1) can clear cisplatin- (CP-) induced excessive reactive oxygen species (ROS), but exogenous SOD1 cannot enter cells because of its low biomembrane permeability. Cell-penetrating peptides (CPPs) can rapidly cross plasma membranes. This study is aimed at identifying an efficient and stable CPP-SOD1 and investigating its effects on CP-induced nephrotoxicity. We recombined SOD1 with 14 different CPPs and purified them using an NTA-Ni

Indexed as

AnimalsCell-Penetrating PeptidesCisplatinKidney DiseasesMaleMiceOxidative Stressp38 Mitogen-Activated Protein KinasesSignal TransductionSuperoxide DismutaseCell-Penetrating PeptidesCisplatinp38 Mitogen-Activated Protein KinasespenetratinSuperoxide Dismutase

Identifiers

PMID34471466

DOI10.1155/2021/5526053

PMCPMC8405295

OpenAlexW3193506607

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.