Evidence map›Paper›PMID 34471461›Full record

ArticleOxidative medicine and cellular longevity2021

Paving Plant-Food-Derived Bioactives as Effective Therapeutic Agents in Autism Spectrum Disorder.

Natália Cruz-Martins, Cristina Quispe, Celale Kırkın, Ezgi Şenol, Aslı Zuluğ, Beraat Özçelik, Adedayo O Ademiluyi, Olubukola Helen Oyeniran, Prabhakar Semwal, Manoj Kumar and 8 more

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 15 institutions in 11 countries.

Natália Cruz-MartinsFaculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.ORCID https://orcid.org/0000-0002-5934-5201
Cristina QuispeFacultad de Ciencias de la Salud, Universidad Arturo Prat, Avda. Arturo Prat 2120, Iquique 1110939, Chile.
Celale KırkınDepartment of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Maslak, 34469 Istanbul, Turkey.
Ezgi ŞenolDepartment Food Engineering, Faculty of Engineering and Natural Sciences, Istanbul Sabahattin Zaim University, Beyoglu, 34427 Istanbul, Turkey.
Aslı ZuluğDepartment of Gastronomy and Culinary Arts, School of Applied Sciences, Ozyegin University, Cekmekoy, 34794 Istanbul, Turkey.
Beraat ÖzçelikDepartment Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Maslak, 34469 Istanbul, Turkey.ORCID https://orcid.org/0000-0002-1810-8154
Adedayo O AdemiluyiFunctional Foods, Nutraceuticals, and Phytomedicine Unit, Department of Biochemistry, Federal University of Technology, Akure 340001, Nigeria.
Olubukola Helen OyeniranFunctional Foods, Nutraceuticals, and Phytomedicine Unit, Department of Biochemistry, Federal University of Technology, Akure 340001, Nigeria.
Prabhakar SemwalDepartment of Biotechnology, Graphic Era University, Dehradun, Uttarakhand, India.ORCID https://orcid.org/0000-0001-5137-5169
Manoj KumarChemical and Biochemical Processing Division, ICAR - Central Institute for Research on Cotton Technology, Mumbai 400019, India.ORCID https://orcid.org/0000-0002-4192-6497
Farukh SharopovDepartment of Pharmaceutical Technology, Avicenna Tajik State Medical University, Rudaki 139, 734003 Dushanbe, Tajikistan.
Victor LópezFacultad de Ciencias de la Salud, Universidad San Jorge, Villanueva de Gállego, Zaragoza, Spain.
Francisco LesFacultad de Ciencias de la Salud, Universidad San Jorge, Villanueva de Gállego, Zaragoza, Spain.ORCID https://orcid.org/0000-0002-7972-7119
Iulia-Cristina BagiuVictor Babes University of Medicine and Pharmacy of Timisoara, Department of Microbiology, Timisoara, Romania.ORCID https://orcid.org/0000-0003-3099-8249
Monica ButnariuBanat's University of Agricultural Sciences and Veterinary Medicine "King Michael I of Romania" from Timisoara, Timisoara, Romania.ORCID https://orcid.org/0000-0002-2032-5000
Javad Sharifi-RadPhytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0002-7301-8151
Mohammed M AlshehriPharmaceutical Care Department, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia.ORCID https://orcid.org/0000-0002-2041-4695
William C ChoDepartment of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong.ORCID https://orcid.org/0000-0003-4174-4586
Federal University of Technology · NGIstanbul Technical University · TRUniversidad de Zaragoza · ESArturo Prat University · CLICAR - Central Institute for Research on Cotton Technology · INİstanbul Sabahattin Zaim Üniversitesi · TRNational Guard Health Affairs · SAÖzyeğin University · TRQueen Elizabeth Hospital · CNShahid Beheshti University of Medical Sciences · IRTajik State Medical University · TJUniversidade do Porto · PTUnivesity of Life Science "King Mihai I" from Timisoara · ROUttarakhand State Council for Science and Technology · INVictor Babeș University of Medicine and Pharmacy Timișoara · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental disorder, where social and communication deficits and repetitive behaviors are present. Plant-derived bioactives have shown promising results in the treatment of autism. In this sense, this review is aimed at providing a careful view on the use of plant-derived bioactive molecules for the treatment of autism. Among the plethora of bioactives, curcumin, luteolin, and resveratrol have revealed excellent neuroprotective effects and can be effectively used in the treatment of neuropsychological disorders. However, the number of clinical trials is limited, and none of them have been approved for the treatment of autism or autism-related disorder. Further clinical studies are needed to effectively assess the real potential of such bioactive molecules.

Indexed as

Autism Spectrum DisorderHumansPlants

Identifiers

PMID34471461
PMCPMC8405324
OpenAlexW3195999195

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.