Evidence map›Paper›PMID 34471424›Full record

ArticleTherapeutic advances in neurological disorders2021

Do somatosensory deficits predict efficacy of neurorehabilitation using neuromuscular electrical stimulation for moderate to severe motor paralysis of the upper limb in chronic stroke?

Keita Tsuzuki, Michiyuki Kawakami, Takuya Nakamura, Osamu Oshima, Nanako Hijikata, Mabu Suda, Yuka Yamada, Kohei Okuyama, Tetsuya Tsuji

Open access · goldAbstract read
In one paragraph

Article in Therapeutic advances in neurological disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Keita TsuzukiDepartment of Rehabilitation Medicine, School of Medicine, Keio University, Tokyo, Japan.ORCID https://orcid.org/0000-0001-7473-6908
Michiyuki KawakamiDepartment of Rehabilitation Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.ORCID https://orcid.org/0000-0001-6459-3325
Takuya NakamuraDepartment of Rehabilitation Medicine, School of Medicine, Keio University, Tokyo, Japan.
Osamu OshimaDepartment of Rehabilitation Medicine, School of Medicine, Keio University, Tokyo, Japan.
Nanako HijikataDepartment of Rehabilitation Medicine, School of Medicine, Keio University, Tokyo, Japan.ORCID https://orcid.org/0000-0002-7911-8567
Mabu SudaDepartment of Rehabilitation Medicine, School of Medicine, Keio University, Tokyo, Japan.
Yuka YamadaDepartment of Rehabilitation Medicine, School of Medicine, Keio University, Tokyo, Japan.
Kohei OkuyamaDepartment of Rehabilitation Medicine, School of Medicine, Keio University, Tokyo, Japan.
Tetsuya TsujiDepartment of Rehabilitation Medicine, School of Medicine, Keio University, Tokyo, Japan.
Keio University · JPKeio University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVarious neurorehabilitation programs have been developed to promote recovery from motor impairment of upper extremities. However, the response of patients with chronic-phase stroke varies greatly. Prediction of the treatment response is important to provide appropriate and efficient rehabilitation. This study aimed to clarify whether clinical assessments, such as motor impairments and somatosensory deficits, before treatment could predict the treatment response in neurorehabilitation.

methodsThe data from patients who underwent neurorehabilitation using closed-loop electromyography (EMG)-controlled neuromuscular electrical stimulation were retrospectively analyzed. A total of 66 patients with chronic-phase stroke with moderate to severe paralysis were included. The changes from baseline in the Fugl-Meyer Assessment-Upper Extremity (FMA-UE) and the Motor Activity Log-14 (MAL-14) of amount of use (AOU) and quality of movement (QOM) were used to assess treatment response, and multivariate logistic regression analysis was performed using the extracted candidate predictors, such as baseline clinical assessments, to identify predictors of FMA-UE and MAL-14 improvement.

resultsFMA-UE and MAL-14 scores improved significantly after the intervention (FMA-UE

conclusionBoth motor and tactile sensory impairments predict improvement in motor function, tactile sensory impairment predicts improvement in the amount of paralytic hand use, and motor impairment predicts improvement in the quality of paralytic hand use following neurorehabilitation treatment in patients with moderate to severe paralysis in chronic-phase stroke. These findings may help select the appropriate treatment for patients with more severe paralysis and to maximize the treatment effect.

Indexed as

chronic strokemotor functionmotor recoveryneurorehabilitationprediction modelsomatosensory function

Identifiers

PMID34471424
PMCPMC8404636
OpenAlexW3197755253

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.