ArticleNature2021
The polar oxy-metabolome reveals the 4-hydroxymandelate CoQ10 synthesis pathway.
Registry-linked trialAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05848271 (A Patient Registry and Natural History Study of Patients with Biallelic HPDL Mutations), which is not on this map. Cited by 38 papers.
0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Patient Registry and Natural History Study of Patients with Biallelic HPDL Mutations
Who cites it
38 citing papers in PubMed.
- CoQExperimental & molecular medicine · 2026Review
- Bypass Treatments for Primary Coenzyme Q10 Deficiency: An Update.International journal of molecular sciences · 2026Review
- Excess cysteine drives conjugate formation and impairs proliferation of NRF2-activated cancer cells.Nature metabolism · 2026Article
- A bioinorganic view on the potential chemical space of hydroxyphenylpyruvate dioxygenase-like (HPDL) enzymes.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026Article
- Loss of function variants in HPDL impair human cortical development via alterations of mitochondrial function.Cell death & disease · 2026Article
- Mitochondrial Dysfunctions in Human Primary Coenzyme QBiomolecules · 2026Review
- Imaging patterns of paediatric CNS mitochondrial disorders.Neuroradiology · 2026Review
- Molecular mechanisms of excitotoxicity and their relevance to the pathogenesis of neurodegenerative diseases-an update.Acta pharmacologica Sinica · 2025Review
- Extracellular Vesicles From Chylomicron-Treated Endothelial Cells Drive Macrophage Inflammation.Arteriosclerosis, thrombosis, and vascular biology · 2025Article
- The integral membrane protein smim4 modulates redox balance via malate compartmentalization in pancreatic cancer.Nature communications · 2025Article
- Article
- Article
- Article
- HPDL Variant Type Correlates With Clinical Disease Onset and Severity.Annals of clinical and translational neurology · 2025Observational
- Natural Hydroxybenzoic and Hydroxycinnamic Acids Derivatives: Mechanisms of Action and Therapeutic Applications.Antioxidants (Basel, Switzerland) · 2025Review
- Exotropia in a Patient With a Novel Homozygous 4-Hydroxyphenylpyruvate Dioxygenase-Like Protein (HPDL) Variant.Cureus · 2025Article
- Quantitative natural history modeling of HPDL-related disease based on cross-sectional data reveals genotype-phenotype correlations.Genetics in medicine : official journal of the American College of Medical Genetics · 2025Article
- Generation and Characterization of hiPS Lines from Three Patients Affected by Different Forms ofInternational journal of molecular sciences · 2024Article
- A novel homozygous HPDL variant in Japanese siblings with autosomal recessive hereditary spastic paraplegia: case report and literature review.Neurogenetics · 2024Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Robert S BanhDepartment of Radiation Oncology, New York University Langone Health, New York, NY, USA.
Esther S KimDepartment of Radiation Oncology, New York University Langone Health, New York, NY, USA.
Quentin SpillierDepartment of Radiation Oncology, New York University Langone Health, New York, NY, USA.
Douglas E BiancurDepartment of Radiation Oncology, New York University Langone Health, New York, NY, USA.
Keisuke YamamotoDepartment of Radiation Oncology, New York University Langone Health, New York, NY, USA.ORCID http://orcid.org/0000-0002-6323-9540
Albert S W SohnDepartment of Radiation Oncology, New York University Langone Health, New York, NY, USA.
Guangbin ShiDepartment of Radiation Oncology, New York University Langone Health, New York, NY, USA.
Drew R JonesMetabolomics Core Resource Laboratory, New York University Langone Health, New York, NY, USA.
Alec C KimmelmanDepartment of Radiation Oncology, New York University Langone Health, New York, NY, USA.
Michael E PacoldDepartment of Radiation Oncology, New York University Langone Health, New York, NY, USA. michael.pacold@nyulangone.org.ORCID http://orcid.org/0000-0003-3688-2378
Funding
Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ANIRBAN MAITRA · 1985 to 2026
$83.1MThe RAS and P13K Pathways in Pancreatic AdenocarcinomaP01CA117969 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DEPINHO, RONALD ANTHONY · 2006 to 2025
$41.7MTRAINING PROGRAM IN MOLECULAR ONCOLOGY &IMMUNOLOGYT32CA009161 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CARROLL, WILLIAM L., LEVY, DAVID E · 1985 to 2020
$13.3MIdentifying Metabolic Dependencies of Pancreatic CancersR35CA232124 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KIMMELMAN, ALEC · 2018 to 2024
$6.5MNetwork organization of the human autophagy systemR01GM095567 · NIGMS · HARVARD MEDICAL SCHOOL · PI HARPER, JEFFREY W, KIMMELMAN, ALEC · 2011 to 2018
$3.0MInvestigating the Role of Autophagy in Pancreatic Cancer Radiation ResistanceR01CA157490 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KIMMELMAN, ALEC · 2011 to 2018
$2.5MRole of nonsense mediated RNA decay in pancreatic cancerR01CA211687 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI PHILIPS, MARK REID · 2018 to 2022
$2.1MInvestigating a Novel Glutamine Metabolism Pathway in Pancreatic CancerR01CA188048 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KIMMELMAN, ALEC · 2015 to 2018
$1.5MSmall molecule approaches to studying tumor metabolismK22CA212059 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI PACOLD, MICHAEL EDWARD · 2017 to 2019
$454kIdentifying Metabolic Vulnerabilities in Pancreatic CancerF99CA245822 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BIANCUR, DOUGLAS · 2019 to 2020
$92kNCI NIH HHS F99 CA245822NCI NIH HHS K22 CA212059NCI NIH HHS P01 CA117969NCI NIH HHS P30 CA016087NCI NIH HHS R01 CA157490NCI NIH HHS R01 CA188048NCI NIH HHS R01 CA211687NCI NIH HHS R35 CA232124NCI NIH HHS T32 CA009161NIGMS NIH HHS R01 GM095567
Abstract
Oxygen is critical for a multitude of metabolic processes that are essential for human life. Biological processes can be identified by treating cells with
Indexed as
Metabolome4-Hydroxyphenylpyruvate DioxygenaseAnimalsCell LineFemaleHumansMandelic AcidsMiceMice, NudeTyrosineUbiquinone4-hydroxymandelic acid4-Hydroxyphenylpyruvate Dioxygenasecoenzyme Q10Mandelic AcidsTyrosineUbiquinone
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
NCT05848271ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.