Evidence map›Paper›PMID 34471259›Full record

ReviewBritish journal of cancer2021

Timeliness of diagnosis and treatment: the challenge of childhood cancers.

Callum J R Mullen, Ronald D Barr, Eduardo L Franco

Erratum issuedOpen access · greenAbstract readReview
In one paragraph

Review in British journal of cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 56 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Pediatric emergency care: Determinants and systematic barriers.World journal of clinical pediatrics · 2025
    Review
  11. Article
  12. Understanding the influence of social determinants of health on symptom reporting in pediatric cancer.The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Unlocking delays: revealing barriers to early diagnosis of childhood central nervous system tumors in an upper-middle-income country.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Callum J R MullenDivision of Cancer Epidemiology, McGill University, Montréal, QC, Canada.ORCID http://orcid.org/0000-0003-0794-8278
Ronald D BarrDepartment of Pediatrics, McMaster University, Hamilton, ON, Canada.ORCID http://orcid.org/0000-0002-5711-7440
Eduardo L FrancoDivision of Cancer Epidemiology, McGill University, Montréal, QC, Canada. eduardo.franco@mcgill.ca.ORCID http://orcid.org/0000-0002-4409-8084
McGill University · CAMcGill University Health Centre · CAMcMaster University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer represents an important cause of disease-related death in children worldwide. Improved treatment and understanding of the ways in which cancer manifests has allowed for a greater prospect of survival in children of all ages. However, variation in childhood cancer experience exists based on factors at the individual, community and systems levels. Throughout the cancer care continuum these factors may influence the access and timeliness of care a child receives, leading to delays in diagnosis and treatment. The pejorative designation 'delay in diagnosis and treatment' is better characterised as lag time, representing an interval that is thought to influence survival and overall outcome. In recent decades, work has been done to expedite early childhood cancer diagnosis through the creation of screening and education-based programmes. Although systematic cancer screening in children poses risks and fails to achieve the goal of early diagnosis, a case has been made for risk-based surveillance that has been shown to improve outcome and reduce occurrence of advanced stage disease in targeted populations. The components of lag time are examined separately and individually. This review highlights the challenges of early diagnosis in childhood cancers and describes important contributors in the cancer care continuum.

Indexed as

AdolescentChildChild, PreschoolEarly Detection of CancerFemaleHumansInfantInfant, NewbornMaleNeoplasms

Identifiers

PMID34471259
PMCPMC8651632
OpenAlexW3198184344

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.