ArticleCommunications biology2021
Frontoparietal network resilience is associated with protection against cognitive decline in Parkinson's disease.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Parkinson's disease and the concept of resilience, cognitive, and motor reserve.Journal of Parkinson's disease · 2026Review
- Dynamic functional connectivity is related to cognitive performance of prodromal Lewy body dementia.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Association between processing speed and segregation/integration of large-scale functional networks in middle-aged and older people living with HIV.BMC neurology · 2026Article
- Characteristics and mechanisms of cognitive impairment in Parkinson disease.Nature reviews. Neurology · 2026Review
- Multimodal data-driven eye-movement subtypes and their cerebral glucose metabolic patterns in Parkinson's disease.Frontiers in aging neuroscience · 2026Article
- Early functional network alterations predict motor and cognitive decline in parkinson's disease.Scientific reports · 2025Article
- Cortical dynamics and network alterations in Parkinson's disease with mild cognitive impairment: TMS-EEG study of the posterior parietal cortex.NPJ Parkinson's disease · 2025Article
- Sex-Specific Association Between XPC rs2228001 Polymorphism and Parkinson's Disease Risk in a Mexican Population: A Case-Control Study Exploring Gene-Environment Interactions.Brain sciences · 2025Article
- Physical activity and network attack tolerance preserve motor function in Parkinson's disease: A pilot study.NPJ Parkinson's disease · 2025Article
- Impaired brain ability of older adults to transit and persist to latent states with well-organized structures at wakeful rest.GeroScience · 2025Article
- The Comparison of Functional Connectivity in Parkinson's Disease Patients with and without Parkin Gene Mutations.Noro psikiyatri arsivi · 2025Article
- Resting-State Functional MRI Approaches to Parkinsonisms and Related Dementia.Current neurology and neuroscience reports · 2024Review
- The Contribution of Cognitive Control Networks in Word Selection Processing in Parkinson's Disease: Novel Insights from a Functional Connectivity Study.Brain sciences · 2024Article
- Pathologic Substrates of Structural Brain Network Resilience and Topology in Parkinson Disease Decedents.Neurology · 2024Article
- Pathobiology of Cognitive Impairment in Parkinson Disease: Challenges and Outlooks.International journal of molecular sciences · 2023Review
- Cerebellar Volume and Disease Staging in Parkinson's Disease: An ENIGMA-PD Study.Movement disorders : official journal of the Movement Disorder Society · 2023Article
- Association between gene expression and functional-metabolic architecture in Parkinson's disease.Human brain mapping · 2023Article
- Accumulation of network redundancy marks the early stage of Alzheimer's disease.Human brain mapping · 2023Article
- Altered brain networks and connections in chronic heart failure patients complicated with cognitive impairment.Frontiers in aging neuroscience · 2023Article
- Resting-state functional connectivity is modulated by cognitive reserve in early Parkinson's disease.Frontiers in psychology · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Though Parkinson's disease is primarily defined as a movement disorder, it is also characterized by a range of non-motor symptoms, including cognitive decline. The onset and progression of cognitive decline in individuals with Parkinson's disease is variable, and the neurobiological mechanisms that contribute to, or protect against, cognitive decline in Parkinson's disease are poorly understood. Using resting-state functional magnetic resonance imaging data collected from individuals with Parkinson's disease with and without cognitive decline, we examined the relationship between topological brain-network resilience and cognition in Parkinson's disease. By leveraging network attack analyses, we demonstrate that relative to individuals with Parkinson's disease experiencing cognitive decline, the frontoparietal network in cognitively stable individuals with Parkinson's disease is significantly more resilient to network perturbation. Our findings suggest that the topological robustness of the frontoparietal network is associated with the absence of cognitive decline in individuals with Parkinson's disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.