ArticleScientific reports2021
Delivery mode and perinatal antibiotics influence the predicted metabolic pathways of the gut microbiome.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Microbial-derived tryptophan metabolites in the infant gut associate with increased risk of asthma following cesarean section.Nature communications · 2026Article
- Perinatal antibiotics in a db/db mouse model impact obesity and hyperglycemia in a microbiome-dependent manner.Frontiers in microbiomes · 2026Article
- Neonatal microbiome in the multiomics era: development and its impact on long-term health.Pediatric research · 2025Review
- Intrapartum antibiotic exposure and infectious diseases in childhood - a population-based cohort study.EBioMedicine · 2024Article
- Early life exposure of infants to benzylpenicillin and gentamicin is associated with a persistent amplification of the gut resistome.Microbiome · 2024Article
- Delivery Mode and Perinatal Antibiotics Influence the Infant Gut Bacteriome and Mycobiome: A Network Analysis.Journal of fungi (Basel, Switzerland) · 2023Article
- The gut microbiome and early-life growth in a population with high prevalence of stunting.Nature communications · 2023Article
- Intestinal Microbiota in Children with Anemia in Southern Peru through Next-Generation Sequencing Technology.Children (Basel, Switzerland) · 2022Article
- Complementary Feeding and Iron Status: "Nutrients · 2021Review
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Delivery mode and perinatal antibiotics influence gut microbiome composition in children. Most microbiome studies have used the sequencing of the bacterial 16S marker gene but have not reported the metabolic function of the gut microbiome, which may mediate biological effects on the host. Here, we used the PICRUSt2 bioinformatics tool to predict the functional profiles of the gut microbiome based on 16S sequencing in two child cohorts. Both Caesarean section and perinatal antibiotics markedly influenced the functional profiles of the gut microbiome at the age of 1 year. In machine learning analysis, bacterial fatty acid, phospholipid, and biotin biosynthesis were the most important pathways that differed according to delivery mode. Proteinogenic amino acid biosynthesis, carbohydrate degradation, pyrimidine deoxyribonucleotide and biotin biosynthesis were the most important pathways differing according to antibiotic exposure. Our study shows that both Caesarean section and perinatal antibiotics markedly influence the predicted metabolic profiles of the gut microbiome at the age of 1 year.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.