Evidence map›Paper›PMID 34471205›Full record

ArticleScientific reports2021

Development and validation of a rapidly deployable CT-guided stereotactic system for external ventricular drainage: preclinical study.

Abhijeet S Barath, Aaron E Rusheen, Juan M Rojas Cabrera, Hojin Shin, Charles D Blaha, Kevin E Bennet, Stephan J Goerss, Kendall H Lee, Yoonbae Oh

Open access · goldAbstract readValidation Study
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. The venous angle as an anatomical landmark to evaluate external ventricular catheter placement.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Abhijeet S BarathDepartment of Neurologic Surgery, Mayo Clinic, Rochester, MN, 55905, USA.
Aaron E RusheenDepartment of Neurologic Surgery, Mayo Clinic, Rochester, MN, 55905, USA.
Juan M Rojas CabreraDepartment of Neurologic Surgery, Mayo Clinic, Rochester, MN, 55905, USA.
Hojin ShinDepartment of Neurologic Surgery, Mayo Clinic, Rochester, MN, 55905, USA.
Charles D BlahaDepartment of Neurologic Surgery, Mayo Clinic, Rochester, MN, 55905, USA.
Kevin E BennetDepartment of Neurologic Surgery, Mayo Clinic, Rochester, MN, 55905, USA.
Stephan J GoerssNaviNetics Inc., Rochester, MN, 55905, USA.
Kendall H LeeDepartment of Neurologic Surgery, Mayo Clinic, Rochester, MN, 55905, USA. lee.kendall@mayo.edu.
Yoonbae OhDepartment of Neurologic Surgery, Mayo Clinic, Rochester, MN, 55905, USA. oh.yoonbae@mayo.edu.
Mayo Clinic · USRecombinetics (United States) · USWinnMed · USMayo Clinic in Florida · US

Funding

TRAINING IN TRANSLATIONAL RESEARCH: BENCH TO BEDSIDER25GM055252 · NIGMS · MAYO CLINIC ROCHESTER · PI LUJAN, LUIS, MAHER, LOUIS JAMES · 1996 to 2022
$8.3M
NRSA Training CoreTL1TR002380 · NCATS · MAYO CLINIC ROCHESTER · PI Felicity T. B. Enders, ANTHONY John WINDEBANK · 2017 to 2026
$6.0M
Medical Scientist Traning Program at Mayo ClinicT32GM065841 · NIGMS · MAYO CLINIC ROCHESTER · PI KAUFMANN, SCOTT H, SCHIMMENTI, LISA A · 2003 to 2022
$5.8M
Mechanism of CMPf Deep Brain Stimulation for Tourette SyndromeF31NS115202 · NINDS · MAYO CLINIC ROCHESTER · PI RUSHEEN, AARON ELLIOTT · 2020 to 2023
$195k
NCATS NIH HHS TL1 TR002380NIGMS NIH HHS R25 GM055252NIGMS NIH HHS T32 GM065841NINDS NIH HHS F31 NS115202
6 · The paper itself

Abstract

External ventricular drainage (EVD) is an emergency neurosurgical procedure to decrease intracranial pressure through a catheter mediated drainage of cerebrospinal fluid. Most EVD catheters are placed using free hands without direct visualization of the target and catheter trajectory, leading to a high rate of complications- hemorrhage, brain injury and suboptimal catheter placement. Use of stereotactic systems can prevent these complications. However, they have found limited application for this procedure due to their long set-up time and expensive hardware. Therefore, we have developed and pre-clinically validated a novel 3D printed stereotactic system for rapid and accurate implantation of EVD catheters. Its mechanical and imaging accuracies were found to be at par with clinical stereotactic systems. Preclinical trial in human cadaver specimens revealed improved targeting accuracy achieved within an acceptable time frame compared to the free hand technique. CT angiography emulated using cadaver specimen with radio-opaque vascular contrast showed vessel free catheter trajectory. This could potentially translate to reduced hemorrhage rate. Thus, our 3D printed stereotactic system offers the potential to improve the accuracy and safety of EVD catheter placement for patients without significantly increasing the procedure time.

Indexed as

Stereotaxic TechniquesDrainageHumansIntracranial HypertensionNeurosurgical ProceduresTomography, X-Ray Computed

Identifiers

PMID34471205
PMCPMC8410845
OpenAlexW3198820429

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.