Evidence map›Paper›PMID 34471196›Full record

ArticleScientific reports2021

Assessing the extent and timing of chemosensory impairments during COVID-19 pandemic.

Cinzia Cecchetto, Antonella Di Pizio, Federica Genovese, Orietta Calcinoni, Alberto Macchi, Andreas Dunkel, Kathrin Ohla, Sara Spinelli, Michael C Farruggia, Paule V Joseph and 8 more

Abstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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  4. Unique and shared patterns of chemosensory dysfunction distinguish chronic COVID-19 and aspirin-exacerbated respiratory disease.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Cinzia CecchettoDepartment of General Psychology, University of Padova, Padua, Italy.
Antonella Di PizioLeibniz-Institute for Food Systems Biology at the Technical University of Munich, Munich, Germany.
Federica GenoveseMonell Chemical Senses Center, Philadelphia, USA.
Orietta CalcinoniPrivate Practice VMPCT, Milan, Italy.
Alberto MacchiENT Department, Italian Academy of Rhinology-ASST sette laghi, Varese, Italy.
Andreas DunkelLeibniz-Institute for Food Systems Biology at the Technical University of Munich, Munich, Germany.
Kathrin OhlaExperimental Psychology Unit, Helmut-Schmidt-University/University of the Federal Armed Forces Hamburg, Hamburg, Germany.
Sara SpinelliDepartment of Agriculture, Food, Environment and Forestry (DAGRI), University of Florence, Florence, Italy.
Michael C FarruggiaInterdepartmental Neuroscience Program, Yale University, New Haven, USA.
Paule V JosephNational Institutes of Nursing Research, Bethesda, USA.
Anna MeniniNeurobiology Section, SISSA, International School for Advanced Studies, Trieste, Italy.
Elena CantoneDepartment of Neuroscience, Reproductive and Odontostomatological Sciences, Ear, Nose and Throat (ENT) Section, University of Naples Federico II, Naples, Italy.
Caterina DinnellaDepartment of Agriculture, Food, Environment and Forestry (DAGRI), University of Florence, Florence, Italy.
Maria Paola CecchiniDepartment of Neurosciences, Biomedicine and Movement Sciences, Anatomy and Histology Section, University of Verona, Verona, Italy.
Anna D'ErricoDepartment of Neurobiology, Goethe Universität Frankfurt, Frankfurt, Germany.
Carla Mucignat-CarettaDepartment of Molecular Medicine, University of Padova, Padua, Italy.
Valentina ParmaMonell Chemical Senses Center, Philadelphia, USA.
Michele DibattistaDepartment of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari A. Moro, Piazza Giulio Cesare n.11, 70124, Bari, Italy. michele.dibattista@uniba.it.

Funding

Sensory Science and Metabolism; Molecular and Neuronal Mechanisms ZIAAA000136 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI JOSEPH, PAULE · 2021 to 2025
$3.2M
Trigeminal Modulation of Olfactory Responses in the Main Olfactory EpitheliumR21DC018358 · NIDCD · MONELL CHEMICAL SENSES CENTER · PI GENOVESE, FEDERICA · 2020 to 2022
$465k
NIDCD NIH HHS R21 DC018358
6 · The paper itself

Abstract

Chemosensory impairments have been established as a specific indicator of COVID-19. They affect most patients and may persist long past the resolution of respiratory symptoms, representing an unprecedented medical challenge. Since the SARS-CoV-2 pandemic started, we now know much more about smell, taste, and chemesthesis loss associated with COVID-19. However, the temporal dynamics and characteristics of recovery are still unknown. Here, capitalizing on data from the Global Consortium for Chemosensory Research (GCCR) crowdsourced survey, we assessed chemosensory abilities after the resolution of respiratory symptoms in participants diagnosed with COVID-19 during the first wave of the pandemic in Italy. This analysis led to the identification of two patterns of chemosensory recovery, partial and substantial, which were found to be associated with differential age, degrees of chemosensory loss, and regional patterns. Uncovering the self-reported phenomenology of recovery from smell, taste, and chemesthetic disorders is the first, yet essential step, to provide healthcare professionals with the tools to take purposeful and targeted action to address chemosensory disorders and their severe discomfort.

Indexed as

AdultAgedClinical Decision-MakingCOVID-19FemaleHumansItalyMaleMiddle AgedOlfaction DisordersSelf ReportTaste DisordersYoung Adult

Identifiers

PMID34471196
PMCPMC8410776

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.