Evidence map›Paper›PMID 34471130›Full record

ArticleNature communications2021

A CDK-regulated chromatin segregase promoting chromosome replication.

Erika Chacin, Priyanka Bansal, Karl-Uwe Reusswig, Luis M Diaz-Santin, Pedro Ortega, Petra Vizjak, Belen Gómez-González, Felix Müller-Planitz, Andrés Aguilera, Boris Pfander and 2 more

Abstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Erika Chacin *Molecular Biology Division, Biomedical Center Munich, Ludwig-Maximilians-Universität, Munich, Planegg-Martinsried, Germany.
Priyanka Bansal *Molecular Biology Division, Biomedical Center Munich, Ludwig-Maximilians-Universität, Munich, Planegg-Martinsried, Germany.
Karl-Uwe ReusswigMax Planck Institute of Biochemistry, DNA Replication and Genome Integrity, Planegg-Martinsried, Germany.ORCID 0000-0003-2544-4145
Luis M Diaz-SantinDepartment of Structural and Molecular Biology, Institute of Structural and Molecular Biology, University College London, London, UK.
Pedro OrtegaAndalusian Molecular Biology and Regenerative Medicine Centre-CABIMER, University of Seville-CSIC, Seville, Spain.
Petra VizjakMolecular Biology Division, Biomedical Center Munich, Ludwig-Maximilians-Universität, Munich, Planegg-Martinsried, Germany.
Belen Gómez-GonzálezAndalusian Molecular Biology and Regenerative Medicine Centre-CABIMER, University of Seville-CSIC, Seville, Spain.ORCID 0000-0003-1655-8407
Felix Müller-PlanitzMolecular Biology Division, Biomedical Center Munich, Ludwig-Maximilians-Universität, Munich, Planegg-Martinsried, Germany.ORCID 0000-0001-8273-6473
Andrés AguileraAndalusian Molecular Biology and Regenerative Medicine Centre-CABIMER, University of Seville-CSIC, Seville, Spain.ORCID 0000-0003-4782-1714
Boris PfanderMax Planck Institute of Biochemistry, DNA Replication and Genome Integrity, Planegg-Martinsried, Germany.ORCID 0000-0003-2180-5054
Alan C M CheungDepartment of Structural and Molecular Biology, Institute of Structural and Molecular Biology, University College London, London, UK.
Christoph F KuratMolecular Biology Division, Biomedical Center Munich, Ludwig-Maximilians-Universität, Munich, Planegg-Martinsried, Germany. Christoph.kurat@bmc.med.lmu.de.

Funding

Biotechnology and Biological Sciences Research CouncilMedical Research CouncilWellcome TrustWellcome Trust 102535/Z/13/Z
6 · The paper itself

Abstract

The replication of chromosomes during S phase is critical for cellular and organismal function. Replicative stress can result in genome instability, which is a major driver of cancer. Yet how chromatin is made accessible during eukaryotic DNA synthesis is poorly understood. Here, we report the characterization of a chromatin remodeling enzyme-Yta7-entirely distinct from classical SNF2-ATPase family remodelers. Yta7 is a AAA

Indexed as

Adenosine TriphosphatasesCell Cycle CheckpointsChromatinChromatin Assembly and DisassemblyChromosomal Proteins, Non-HistoneCyclin-Dependent KinasesDNADNA ReplicationHistonesHumansPhosphorylationSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsS PhaseTranscription FactorsAdenosine TriphosphatasesChromatinChromosomal Proteins, Non-HistoneCyclin-Dependent KinasesDNAHistonesSaccharomyces cerevisiae ProteinsSNF2 protein, S cerevisiaeTranscription FactorsYTA7 protein, S cerevisiae

Identifiers

PMID34471130
PMCPMC8410769

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.