ArticleProceedings of the National Academy of Sciences of the United States of America2021
Efficacy and breadth of adjuvanted SARS-CoV-2 receptor-binding domain nanoparticle vaccine in macaques.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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53citing papers in PubMed
3.6field-weighted citation impact, top 5% of its field
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Who cites it
53 citing papers in PubMed, 66 citations in OpenAlex.
- Rapid and robust immune response boosting with potent, next-generation adjuvant in viral vector-primed primates.Journal of virology · 2026Article
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- Biomimetic nanovaccines with self-adjuvant effects induced broad-spectrum neutralizing antibodies against SARS-CoV-2 infection in rodents.Journal of virology · 2025Article
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- A Reassessment of the Genomic Ancestry of the World's Largest Captive Baboon Colony.American journal of primatology · 2025Article
- Protein nanoparticle vaccines induce potent neutralizing antibody responses against MERS-CoV.Cell reports · 2024Article
- SARS-CoV-2 ferritin nanoparticle vaccines produce hyperimmune equine sera with broad sarbecovirus activity.iScience · 2024Article
- Beyond COVID-19: the promise of next-generation coronavirus vaccines.Npj viruses · 2024Review
- Multi-compartmental diversification of neutralizing antibody lineages dissected in SARS-CoV-2 spike-immunized macaques.Nature communications · 2024Article
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- Protein nanoparticle vaccines induce potent neutralizing antibody responses against MERS-CoV.bioRxiv : the preprint server for biology · 2024Article
- Enhancing antibody responses by multivalent antigen display on thymus-independent DNA origami scaffolds.Nature communications · 2024Article
- Enhancing antibody responses by multivalent antigen display on thymus-independent DNA origami scaffolds.Nature communications · 2024Article
- Development of semisynthetic saponin immunostimulants.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2024Review
- Extraordinary Titer and Broad Anti-SARS-CoV-2 Neutralization Induced by Stabilized RBD Nanoparticles from Strain BA.5.Vaccines · 2023Article
- A receptor-binding domain-based nanoparticle vaccine elicits durable neutralizing antibody responses against SARS-CoV-2 and variants of concern.Emerging microbes & infections · 2023Article
- Deciphering triterpenoid saponin biosynthesis by leveraging transcriptome response to methyl jasmonate elicitation in Saponaria vaccaria.Nature communications · 2023Article
- Medium-term scenarios of COVID-19 as a function of immune uncertainties and chronic disease.Journal of the Royal Society, Interface · 2023Article
- Enhancing antibody responses by multivalent antigen display on thymus-independent DNA origami scaffolds.bioRxiv : the preprint server for biology · 2023Article
- SARS-CoV-2 spike-ferritin-nanoparticle adjuvanted with ALFQ induces long-lived plasma cells and cross-neutralizing antibodies.NPJ vaccines · 2023Article
Corrections and comments
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Authors and funding
57 authors at 8 institutions in 1 country.
Hannah A D KingUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
M Gordon JoyceEmerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910.ORCID 0000-0002-6808-7232
Ines Lakhal-NaouarHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817.
Aslaa AhmedViral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
Camila Macedo CincottaHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817.
Caroline SubraUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910.ORCID 0000-0001-5272-0972
Kristina K PeachmanDiagnostics and Countermeasures Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910.ORCID 0000-0001-8568-1439
Holly R HackHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817.
Rita E ChenDepartment of Medicine, Washington University, St. Louis, MO 63130.
Paul V ThomasEmerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
Wei-Hung ChenEmerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
Rajeshwer S SankhalaEmerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
Agnes HajduczkiEmerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
Elizabeth J MartinezEmerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910.ORCID 0000-0002-7755-7056
Caroline E PetersonEmerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
William C ChangEmerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910.ORCID 0000-0003-4967-6426
Misook ChoeEmerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910.ORCID 0000-0003-0243-5203
Clayton SmithCenter for Molecular Microscopy, Center for Cancer Research, National Cancer Institute, NIH, Frederick, MD 21702.
Jarrett A HeadleyEmerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910.ORCID 0000-0001-5809-5485
Hanne A ElyardBIOQUAL, Inc., Rockville, MD 20850.ORCID 0000-0003-1103-9608
Anthony CookBIOQUAL, Inc., Rockville, MD 20850.
Alexander AndersonUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910.ORCID 0000-0002-0000-7734
Kathryn McGuckin WuertzUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
Ming DongUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
Isabella SwaffordUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
James B CaseDepartment of Medicine, Washington University, St. Louis, MO 63130.
Jeffrey R CurrierViral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
Kerri G LalUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910.ORCID 0000-0002-8970-0198
Mihret F AmareEmerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910.ORCID 0000-0002-2696-6116
Vincent DussuptUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
Sebastian MolnarUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
Sharon P DayeCenter for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD 20910.ORCID 0000-0002-1481-3884
Xiankun ZengDivision of Pathology, US Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702.
Erica K BarkeiVeterinary Pathology Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
Kendra AlfsonDisease Intervention and Prevention, Texas Biomedical Research Institute, San Antonio, TX 78227.ORCID 0000-0001-6031-5360
Hilary M StaplesDisease Intervention and Prevention, Texas Biomedical Research Institute, San Antonio, TX 78227.
Ricardo CarrionDisease Intervention and Prevention, Texas Biomedical Research Institute, San Antonio, TX 78227.ORCID 0000-0001-7046-7683
Shelly J KrebsUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
Dominic Paquin-ProulxUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910.ORCID 0000-0003-1407-3414
Nicos KarasavvasHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817.ORCID 0000-0001-7372-4294
Victoria R PolonisUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
Linda L JagodzinskiDiagnostics and Countermeasures Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
Sandhya VasanUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910.ORCID 0000-0002-6378-6288
Paul T ScottEmerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910.ORCID 0000-0002-2348-4541
Yaoxing HuangAaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032.
Manoj S NairAaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032.ORCID 0000-0002-5994-3957
David D HoAaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032.
Natalia de ValCenter for Molecular Microscopy, Center for Cancer Research, National Cancer Institute, NIH, Frederick, MD 21702.ORCID 0000-0002-1506-2023
Michael S DiamondDepartment of Medicine, Washington University, St. Louis, MO 63130.
Mark G LewisBIOQUAL, Inc., Rockville, MD 20850.ORCID 0000-0001-7852-0135
Mangala RaoUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910.ORCID 0000-0001-9553-4969
Gary R MatyasUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
Gregory D GromowskiViral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910.ORCID 0000-0003-4576-4277
Sheila A PeelDiagnostics and Countermeasures Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
Nelson L MichaelCenter for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD 20910.ORCID 0000-0001-5882-5548
Kayvon ModjarradEmerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910; kmodjarrad@eidresearch.org dbolton@hivresearch.org.
Diane L BoltonUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910; kmodjarrad@eidresearch.org dbolton@hivresearch.org.ORCID 0000-0003-1897-499X
Henry M. Jackson Foundation · USWalter Reed Army Institute of Research · USAaron Diamond AIDS Research Center · USBioqual · USTexas Biomedical Research Institute · USWashington University in St. Louis · USNational Cancer Institute · USUnited States Army Medical Research Institute of Infectious Diseases · US
Funding
Human antibody-based countermeasures against the Wuhan Coronavirus SARS-CoV-2R01AI157155 · NIAID · WASHINGTON UNIVERSITY · PI BARIC, RALPH S, CROWE, JAMES E · 2020 to 2024
$6.0MNIAID NIH HHS R01 AI157155
Abstract
Emergence of novel variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) underscores the need for next-generation vaccines able to elicit broad and durable immunity. Here we report the evaluation of a ferritin nanoparticle vaccine displaying the receptor-binding domain of the SARS-CoV-2 spike protein (RFN) adjuvanted with Army Liposomal Formulation QS-21 (ALFQ). RFN vaccination of macaques using a two-dose regimen resulted in robust, predominantly Th1 CD4+ T cell responses and reciprocal peak mean serum neutralizing antibody titers of 14,000 to 21,000. Rapid control of viral replication was achieved in the upper and lower airways of animals after high-dose SARS-CoV-2 respiratory challenge, with undetectable replication within 4 d in seven of eight animals receiving 50 µg of RFN. Cross-neutralization activity against SARS-CoV-2 variant B.1.351 decreased only approximately twofold relative to WA1/2020. In addition, neutralizing, effector antibody and cellular responses targeted the heterotypic SARS-CoV-1, highlighting the broad immunogenicity of RFN-ALFQ for SARS-CoV-like Sarbecovirus vaccine development.
Indexed as
Adjuvants, ImmunologicAnimalsAntibodies, NeutralizingAntibodies, ViralCOVID-19COVID-19 VaccinesFerritinsMacaca mulattaNanoparticlesReceptors, VirusSARS-CoV-2T-LymphocytesAdjuvants, ImmunologicAntibodies, NeutralizingAntibodies, ViralCOVID-19 VaccinesFerritinsReceptors, VirusadjuvantmacaquenanoparticleSARS-CoV-2vaccine
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