ArticleJournal of immunology (Baltimore, Md. : 1950)2021
Layilin Anchors Regulatory T Cells in Skin.
Open access · bronzeAbstract read
In one paragraph
Article in Journal of immunology (Baltimore, Md. : 1950), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- Epigenetic landscape, key transcriptional regulators, and in vivo identification of human Tr1 cells.Science advances · 2026Article
- Regulatory T cells and peripheral immune tolerance: key mechanisms and therapeutic strategies for cardiovascular diseases.Frontiers in immunology · 2026Review
- Immunomodulatory roles of regulatory T cells in cutaneous wound healing: mechanisms and therapeutic opportunities.Frontiers in immunology · 2026Review
- The role of miRNAs in the development of Super-Tregs as a potential therapy for neurodegenerative diseases.Frontiers in immunology · 2026Review
- Article
- Layilin at the crossroads of immunity and motility: a C-type lectin receptor in Hyaluronan Signaling.Glycobiology · 2025Review
- Article
- Immune evasion mechanisms in early-stage I high-grade serous ovarian carcinoma: insights into regulatory T cell dynamics.Cell death & disease · 2025Article
- The profiles of immunosuppressive microenvironment in the Lauren intestinal-type gastric adenocarcinoma.Cancer immunology, immunotherapy : CII · 2025Article
- The dual role of tissue regulatory T cells in tissue repair: return to homeostasis or fibrosis.Frontiers in immunology · 2025Review
- Layilin: a multifunctional hyaluronan receptor in physiology and pathology.Frontiers in oncology · 2025Review
- Diversity of group 1 innate lymphoid cells in human tissues.Nature immunology · 2024Article
- Treg-tissue cell interactions in repair and regeneration.The Journal of experimental medicine · 2024Review
- Tregs from human blood differentiate into nonlymphoid tissue-resident effector cells upon TNFR2 costimulation.JCI insight · 2024Article
- Regulatory T cells in dominant immunologic tolerance.The Journal of allergy and clinical immunology · 2024Review
- Treg cells require Izumo1R to regulate γδT cell-driven inflammation in the skin.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The expanding impact of T-regs in the skin.Frontiers in immunology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 1 institution in 1 country.
Pooja MehtaDepartment of Dermatology, University of California San Francisco, San Francisco, CA.
Victoire GouirandDepartment of Dermatology, University of California San Francisco, San Francisco, CA.ORCID 0000-0002-2666-0061
Devi P BodaDepartment of Dermatology, University of California San Francisco, San Francisco, CA.ORCID 0000-0002-2880-1657
Jingxian ZhangDepartment of Dermatology, University of California San Francisco, San Francisco, CA.
Sofia V GeartyDepartment of Dermatology, University of California San Francisco, San Francisco, CA.ORCID 0000-0001-8633-3663
Bahar ZirakDepartment of Dermatology, University of California San Francisco, San Francisco, CA.
Margaret M LoweDepartment of Dermatology, University of California San Francisco, San Francisco, CA.
Sean ClancyDepartment of Dermatology, University of California San Francisco, San Francisco, CA.
Ian BoothbyDepartment of Dermatology, University of California San Francisco, San Francisco, CA.ORCID 0000-0002-1112-2834
Kelly M MahuronDepartment of Surgery, University of California San Francisco, San Francisco, CA.ORCID 0000-0002-2544-5191
Adam FriesDepartment of Pathology, University of California San Francisco, San Francisco, CA; and.
Matthew F KrummelDepartment of Pathology, University of California San Francisco, San Francisco, CA; and.
Parminder MankooTRexBio, Burlingame, CA.
Hsin-Wen ChangDepartment of Dermatology, University of California San Francisco, San Francisco, CA.
Jared LiuDepartment of Dermatology, University of California San Francisco, San Francisco, CA.ORCID 0000-0001-8481-3129
Joshua M MoreauDepartment of Dermatology, University of California San Francisco, San Francisco, CA.ORCID 0000-0002-1227-1508
Tiffany C ScharschmidtDepartment of Dermatology, University of California San Francisco, San Francisco, CA.ORCID 0000-0001-5517-089X
Adil DaudDepartment of Dermatology, University of California San Francisco, San Francisco, CA.ORCID 0000-0002-6617-8421
Esther KimDepartment of Surgery, University of California San Francisco, San Francisco, CA.
Isaac M NeuhausDepartment of Dermatology, University of California San Francisco, San Francisco, CA.
Hobart W HarrisDepartment of Surgery, University of California San Francisco, San Francisco, CA.ORCID 0000-0002-1196-1558
Wilson LiaoDepartment of Dermatology, University of California San Francisco, San Francisco, CA.ORCID 0000-0001-7883-6439
Michael D RosenblumDepartment of Dermatology, University of California San Francisco, San Francisco, CA; Michael.Rosenblum@ucsf.edu.
University of California, San Francisco · US
Funding
Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GERMAN, MICHAEL S · 2003 to 2019
$21.8MMOLECULAR AND CELLULAR IMMUNOLOGYT32AI007334 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CYSTER, JASON G · 1988 to 2023
$11.0MElucidating the Role of Regulatory T cells in Establishing and Maintaining a Th2 Niche in SkinR01AR077553 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSENBLUM, MICHAEL DAVID · 2020 to 2024
$3.5MFunctional Manipulation of Memory Regulatory T cells in SkinDP2AR068130 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSENBLUM, MICHAEL DAVID · 2014 to 2014
$2.4MElucidating the Cellular and Molecular Mechanisms of How Regulatory T cells in Skin Regulate Fibroblast Activation and Tissue FibrosisR01AR071944 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSENBLUM, MICHAEL DAVID · 2018 to 2022
$1.7MUCSF DVS CyTOF Mass CytometerS10OD018040 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LANIER, LEWIS LEE · 2014 to 2014
$600kElucidating the Functional Role of Layilin Expression on Regulatory T cells in SkinR21AR072195 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSENBLUM, MICHAEL DAVID · 2017 to 2018
$384kNIAID NIH HHS T32 AI007334NIAMS NIH HHS DP2 AR068130NIAMS NIH HHS R01 AR071944NIAMS NIH HHS R01 AR077553NIAMS NIH HHS R21 AR072195NIDDK NIH HHS P30 DK063720NIH HHS S10 OD018040
Abstract
Regulatory T cells (Tregs) reside in nonlymphoid tissues where they carry out unique functions. The molecular mechanisms responsible for Treg accumulation and maintenance in these tissues are relatively unknown. Using an unbiased discovery approach, we identified
Indexed as
AnimalsCarrier ProteinsCell MovementCells, CulturedHumansImmune ToleranceLymphocyte ActivationMembrane GlycoproteinsMiceMice, Inbred C57BLMice, KnockoutModels, ImmunologicalOrgan SpecificityReceptors, Lymphocyte HomingSkinT-Lymphocytes, RegulatoryCarrier Proteinslayilin protein, mouseMembrane GlycoproteinsReceptors, Lymphocyte HomingTransforming Growth Factor beta
Identifiers
What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.