ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021
Developmental Effects of Oxytocin Neurons on Social Affiliation and Processing of Social Information.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
- Multi-transmitter characteristics and functional specialization of oxytocin neuron subpopulations in zebrafish.The Journal of experimental biology · 2026Article
- Nonapeptide cell size differs between male morphs of the West African cichlid, Pelvicachromis pulcher.Journal of fish biology · 2026Article
- Distinct distributed neural dynamics predict pallium-dependent social approach.Nature communications · 2026Article
- Remembering the opponent: neuronal activation associated with social memory in zebrafish.Frontiers in veterinary science · 2026Article
- Oxytocinergic Signaling in Zebrafish: Translational Perspectives for Autism Spectrum Disorder.Journal of neurochemistry · 2026Review
- Single-Cell Peptide Profiling to Distinguish Stickleback Ecotypes with Divergent Breeding Behavior.Journal of proteome research · 2025Article
- The Impact of Oxytocin on Stimulus Discrimination of Zebrafish Albino and Non-Albino Models.International journal of molecular sciences · 2025Article
- Vitamin A attenuates PFOS-induced neurotoxicity and alters early proximity patterns to conspecifics in zebrafish larvae.Frontiers in behavioral neuroscience · 2025Article
- Oxytocin Enhances Time-Dependent Responses in the Aggressive Zebrafish (Brain sciences · 2024Article
- Beyond fur color: differences in socio-emotional behavior and the oxytocin system between male BL6 and CD1 mice in adolescence and adulthood.Frontiers in neuroscience · 2024Article
- Therapeutic uses of oxytocin in stress-related neuropsychiatric disorders.Cell & bioscience · 2023Review
- Brain areas activated during visual learning in the cichlid fish Pseudotropheus zebra.Brain structure & function · 2023Article
- High-throughput functional analysis of autism genes in zebrafish identifies convergence in dopaminergic and neuroimmune pathways.Cell reports · 2023Article
- Altered GABAergic, glutamatergic and endocannabinoid signaling is accompanied by neuroinflammatory response in a zebrafish model of social withdrawal behavior.Frontiers in molecular neuroscience · 2023Article
- Socio-behavioral dysfunction in disorders of hypothalamic-pituitary involvement: The potential role of disease-induced oxytocin and vasopressin signaling deficits.Neuroscience and biobehavioral reviews · 2022Review
- Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities.Endocrinology · 2022Review
- Article
- Role of Brain Modulators in Neurodevelopment: Focus on Autism Spectrum Disorder and Associated Comorbidities.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Oxytocin receptors influence the development and maintenance of social behavior in zebrafish (Danio rerio).Scientific reports · 2022Article
- Sex Differences in Aggression Are Paralleled by Differential Activation of the Brain Social Decision-Making Network in Zebrafish.Frontiers in behavioral neuroscience · 2022Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hormones regulate behavior either through activational effects that facilitate the acute expression of specific behaviors or through organizational effects that shape the development of the nervous system thereby altering adult behavior. Much research has implicated the neuropeptide oxytocin (OXT) in acute modulation of various aspects of social behaviors across vertebrate species, and OXT signaling is associated with the developmental social deficits observed in autism spectrum disorders (ASDs); however, little is known about the role of OXT in the neurodevelopment of the social brain. We show that perturbation of OXT neurons during early zebrafish development led to a loss of dopaminergic neurons, associated with visual processing and reward, and blunted the neuronal response to social stimuli in the adult brain. Ultimately, adult fish whose OXT neurons were ablated in early life, displayed altered functional connectivity within social decision-making brain nuclei both in naive state and in response to social stimulus and became less social. We propose that OXT neurons have an organizational role, namely, to shape forebrain neuroarchitecture during development and to acquire an affiliative response toward conspecifics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.