Evidence map›Paper›PMID 34470793›Full record

ArticleThe Journal of rheumatology2022

Lifestyle Factors and Disease Activity Over Time in Early Axial Spondyloarthritis: The SPondyloArthritis Caught Early (SPACE) Cohort.

Sofia Exarchou, Carl Turesson, Ulf Lindström, Roberta Ramonda, Robert B Landewé, Hanne Dagfinrud, Floris van Gaalen, Désirée van der Heijde, Lennart T Jacobsson

Open access · bronzeAbstract read
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In one paragraph

Article in The Journal of rheumatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 5 countries.

Sofia ExarchouS. Exarchou, MD, PhD, Rheumatology, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden; sofiaexar@hotmail.com.ORCID 0000-0002-9261-7192
Carl TuressonC. Turesson, MD, PhD, Rheumatology, Department of Clinical Sciences Malmö, Lund University, and Department of Rheumatology, Skåne University Hospital, Malmö, Sweden.
Ulf LindströmU. Lindström, MD, PhD, L.T. Jacobsson, MD, PhD, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Roberta RamondaR. Ramonda, MD, PhD, Rheumatology Unit, Department of Medicine DIMED, University of Padua, Padua, Italy.ORCID 0000-0002-9683-8873
Robert B LandewéR.B. Landewé, MD, PhD, Department of Rheumatology, Amsterdam Rheumatology and Immunology Center, Amsterdam, the Netherlands.
Hanne DagfinrudH. Dagfinrud, PT, PhD, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.
Floris van GaalenF. van Gaalen, MD, PhD, D. van der Heijde, MD, PhD, Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands.
Désirée van der HeijdeF. van Gaalen, MD, PhD, D. van der Heijde, MD, PhD, Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands.
Lennart T JacobssonU. Lindström, MD, PhD, L.T. Jacobsson, MD, PhD, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Leiden University Medical Center · NLUniversity of Gothenburg · SECenter for Rheumatology · USDiakonhjemmet Hospital · NOLund University · SEMalmö University · SEUniversity of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveOur aim was to study the importance of baseline BMI, smoking, and alcohol consumption (AC) for disease activity (DA) over 1 year in early axial spondyloarthritis (axSpA), stratified by sex.

methodsIn the SPondyloArthritis Caught Early cohort (patients with chronic back pain onset at age < 45 yrs, with pain for ≥ 3 months and ≤ 2 yrs), the Ankylosing Spondylitis Disease Activity Score (ASDAS) was recorded at inclusion, 3, and 12 months. All patients included in the analysis had axSpA based on a high physician's level of confidence at baseline. Differences in ASDAS over 1 year by BMI (normal < 25 kg/m

resultsThere were 344 subjects (mean age of 30.3 yrs; 49.4% men). In women, obesity was associated with 0.60 (95% CI 0.28-0.91) higher ASDAS compared to normal BMI. In both sexes, AC tended to be associated with lower DA over 1 year, with a significant association only in women with the highest AC (mean difference of -0.55, 95% CI -1.05 to -0.04). Smoking was associated with higher ASDAS over 1 year compared to never smoking in both sexes, although the difference reached statistical significance only in female former smokers. Results were similar in multivariable analysis, adjusted for all lifestyle factors and other confounders.

conclusionIn early axSpA, BMI and smoking are associated with higher DA over 1 year, and AC with lower DA. The magnitude of the modest associations may differ between men and women.

Indexed as

Axial SpondyloarthritisSpondylarthritisSpondylitis, AnkylosingAdultFemaleHumansLife StyleMaleMiddle AgedSeverity of Illness Indexalcohol consumptionbody mass indexcigarette smokinglifestylepatient outcome assessmentspondylarthritis

Identifiers

PMID34470793
OpenAlexW3196579465

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.