Evidence map›Paper›PMID 34470785›Full record

ArticleBMJ (Clinical research ed.)2021

Long term exposure to low level air pollution and mortality in eight European cohorts within the ELAPSE project: pooled analysis.

Maciej Strak, Gudrun Weinmayr, Sophia Rodopoulou, Jie Chen, Kees de Hoogh, Zorana J Andersen, Richard Atkinson, Mariska Bauwelinck, Terese Bekkevold, Tom Bellander and 42 more

Open access · hybridAbstract readMulticenter Study
In one paragraph

Article in BMJ (Clinical research ed.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed, 6 pooled it
22.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

108 citing papers in PubMed, 6 syntheses or guidelines pooled it, 270 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Mortality and Morbidity Effects of Long-Term Exposure to Low-Level PMResearch report (Health Effects Institute) · 2021
    Pooled it
  7. Review
  8. Article
  9. Association between long-term PMBMC public health · 2026
    Article
  10. Impact of PMJournal of environmental health science & engineering · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Mortality impacts of long-term PMAtmospheric pollution research · 2026
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

48 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

52 authors at 20 institutions in 12 countries.

Maciej StrakInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands.
Gudrun WeinmayrInstitute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.
Sophia RodopoulouDepartment of Hygiene, Epidemiology, and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Jie ChenInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands.
Kees de HooghSwiss Tropical and Public Health Institute, Basel, Switzerland.
Zorana J AndersenDepartment of Public Health, Section of Environment and Health, University of Copenhagen, Copenhagen, Denmark.
Richard AtkinsonPopulation Health Research Institute, St George's, University of London, London, UK.
Mariska BauwelinckInterface Demography - Department of Sociology, Vrije Universiteit Brussel, Brussels, Belgium.
Terese BekkevoldDepartment of Method Development and Analytics, Norwegian Institute of Public Health, Oslo, Norway.
Tom BellanderInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Marie-Christine Boutron-RuaultUniversity Paris-Saclay, UVSQ, Inserm, Gustave Roussy, "Exposome and Heredity" Team, CESP UMR1018, Paris, France.
Jørgen BrandtDepartment of Environmental Science, Aarhus University, Roskilde, Denmark.
Giulia CesaroniDepartment of Epidemiology, Lazio Region Health Service/ASL Roma 1, Rome, Italy.
Hans ConcinAgency for Preventive and Social Medicine (AKS), Bregenz, Austria.
Daniela FechtMRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
Francesco ForastiereDepartment of Epidemiology, Lazio Region Health Service/ASL Roma 1, Rome, Italy.
John GulliverMRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
Ole HertelDepartment of Bioscience, Aarhus University, Roskilde, Denmark.
Barbara HoffmannInstitute for Occupational, Social, and Environmental Medicine, Centre for Health and Society, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Ulla Arthur HvidtfeldtDanish Cancer Society Research Center, Copenhagen, Denmark.
Nicole A H JanssenNational Institute for Public Health and the Environment, Bilthoven, Netherlands.
Karl-Heinz JöckelInstitute for Medical Informatics, Biometry, and Epidemiology, Medical Faculty, University of Duisburg-Essen, Essen, Germany.
Jeanette T JørgensenDepartment of Public Health, Section of Environment and Health, University of Copenhagen, Copenhagen, Denmark.
Matthias KetzelDepartment of Environmental Science, Aarhus University, Roskilde, Denmark.
Jochem O KlompmakerNational Institute for Public Health and the Environment, Bilthoven, Netherlands.
Anton LagerDepartment of Global Public Health, Karolinska Institutet, Stockholm, Sweden.
Karin LeanderInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Shuo LiuDepartment of Public Health, Section of Environment and Health, University of Copenhagen, Copenhagen, Denmark.
Petter LjungmanInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Patrik K E MagnussonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Amar J MehtaDepartment of Public Health, Section of Epidemiology, University of Copenhagen, Copenhagen, Denmark.
Gabriele NagelInstitute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.
Bente OftedalDepartment of Environmental Health, Norwegian Institute of Public Health, Oslo, Norway.
Göran PershagenInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Annette PetersInstitute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany.
Ole Raaschou-NielsenDanish Cancer Society Research Center, Copenhagen, Denmark.
Matteo RenziDepartment of Epidemiology, Lazio Region Health Service/ASL Roma 1, Rome, Italy.
Debora RizzutoDepartment of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Stockholm, Sweden.
Yvonne T van der SchouwJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.
Sara SchrammInstitute for Medical Informatics, Biometry, and Epidemiology, Medical Faculty, University of Duisburg-Essen, Essen, Germany.
Gianluca SeveriUniversity Paris-Saclay, UVSQ, Inserm, Gustave Roussy, "Exposome and Heredity" Team, CESP UMR1018, Paris, France.
Torben SigsgaardDepartment of Public Health, Environment, Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark.
Mette SørensenDanish Cancer Society Research Center, Copenhagen, Denmark.
Massimo StafoggiaInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Anne TjønnelandDanish Cancer Society Research Center, Copenhagen, Denmark.
W M Monique VerschurenNational Institute for Public Health and the Environment, Bilthoven, Netherlands.
Danielle VienneauSwiss Tropical and Public Health Institute, Basel, Switzerland.
Kathrin WolfInstitute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany.
Klea KatsouyanniDepartment of Hygiene, Epidemiology, and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Bert BrunekreefInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands.
Gerard HoekInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands g.hoek@uu.nl.ORCID 0000-0003-3687-217X
Evangelia SamoliDepartment of Hygiene, Epidemiology, and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Karolinska Institutet · SEAarhus University · DKUniversity of Copenhagen · DKUtrecht University · NLDanish Cancer Society · DKASL Roma · ITHelmholtz Zentrum München · DEInserm · FRKing's College London · GBNational and Kapodistrian University of Athens · GRNorwegian Institute of Public Health · NOSwiss Tropical and Public Health Institute · CHUniversität Ulm · DEUniversity Medical Center Utrecht · NLUniversity of Duisburg-Essen · DEDanderyds sjukhus · SEHarvard University · USHeinrich Heine University Düsseldorf · DEMRC Centre for Environment and HealthNational Institute for Public Health and the Environment · NL

Funding

Medical Research Council MR/S019669/1
6 · The paper itself

Abstract

objectiveTo investigate the associations between air pollution and mortality, focusing on associations below current European Union, United States, and World Health Organization standards and guidelines.

designPooled analysis of eight cohorts.

settingMulticentre project Effects of Low-Level Air Pollution: A Study in Europe (ELAPSE) in six European countries.

participants325 367 adults from the general population recruited mostly in the 1990s or 2000s with detailed lifestyle data. Stratified Cox proportional hazard models were used to analyse the associations between air pollution and mortality. Western Europe-wide land use regression models were used to characterise residential air pollution concentrations of ambient fine particulate matter (PM

main outcome measuresDeaths due to natural causes and cause specific mortality.

resultsOf 325 367 adults followed-up for an average of 19.5 years, 47 131 deaths were observed. Higher exposure to PM

conclusionsOur study contributes to the evidence that outdoor air pollution is associated with mortality even at low pollution levels below the current European and North American standards and WHO guideline values. These findings are therefore an important contribution to the debate about revision of air quality limits, guidelines, and standards, and future assessments by the Global Burden of Disease.

Indexed as

Air PollutantsAir PollutionCardiovascular DiseasesEnvironmental ExposureEuropeHumansNoncommunicable DiseasesAir Pollutants

Identifiers

PMID34470785
PMCPMC8409282
OpenAlexW3197926939

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.