ReviewThe journal of physiological sciences : JPS2021
Exercise-induced oxidative stress and melatonin supplementation: current evidence.
Review in The journal of physiological sciences : JPS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Dose-response relationship between physical activity and subjective sleep quality in patients with insomnia: a systematic review and Bayesian meta-analysis of randomized controlled trials.The international journal of behavioral nutrition and physical activity · 2026Pooled it
- Effects of different dietary supplements on athletic performance in soccer players: a systematic review and network meta-analysis.Journal of the International Society of Sports Nutrition · 2025Pooled it
- The Impact of Physical Activity on Sleep in Alcohol Users: A Systematic Review.Addiction biology · 2025Pooled it
- Social and circadian rhythm dysregulation and suicide: A systematic review and meta-analysis.Neuroscience and biobehavioral reviews · 2024Pooled it
- Pooled it
- The Effects of Melatonin Supplementation on Professional Football Player Performance: A Systematic Review.Nutrients · 2023Pooled it
- Mood Status Response to Physical Activity and Its Influence on Performance: Are Chronotype and Exercise Timing Affect?International journal of environmental research and public health · 2023Pooled it
- Influence of Acute Melatonin Administration on Human Physical Performance: A Systematic Review.Sports healthPooled it
- Melatonin administered postoperatively lowers oxidative stress and inflammation and significantly recovers heart function in patients undergoing CABG surgery.European journal of medical research · 2025Trial
- Trial
- Association of Domain-Specific Physical Activity with Sleep Disorders in U.S. Adults: A Cross-Sectional Study Based on NHANES.Healthcare (Basel, Switzerland) · 2026Article
- Physical activity and sleep disturbances in individuals with alcohol use disorder: protocol of the APhysOH pilot study for a randomized controlled trial.Addiction science & clinical practice · 2026Article
- The Moderated Mediation Role of Depressive Symptoms and Physical Health in the Relationship Between Physical Exercise and Sleep Quality Among Emerging Adults.Behavioral sciences (Basel, Switzerland) · 2026Article
- Article
- Association between physical activity intensity and nocturia risk: the mediating role of mental health.Journal of health, population, and nutrition · 2026Article
- Synergistic effects of intradialytic concurrent training and melatonin supplementation on immune cell adaptations in hemodialysis patients.Frontiers in pharmacology · 2026Article
- Gender and residential differences in sleep quality among Chinese adolescents aged 13-18 years.PloS one · 2026Article
- The impact of physical exercise on sleep quality among college students: a moderated mediation model.Frontiers in psychiatry · 2026Article
- A study of the relationship between physical fitness index and sleep quality in Chinese adolescents.Sleep & breathing = Schlaf & Atmung · 2025Article
- Sleep quality and body composition in active and inactive young adults.Scientific reports · 2025Observational
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Melatonin possesses the indoleamine structure and exerts antioxidant and anti-inflammatory actions and other physiological properties. Physical exercise can influence secretion of melatonin. Melatonin is used as a natural supplement among athletes to regulate sleep cycles and protect muscles against oxidative damage. Despite decades of research, there is still a lack of a comprehensive and critical review on melatonin supplementation and physical activity relationship. The aim of this literature review is to examine the antioxidant, anti-inflammatory and other biological functions played by melatonin with reference to the effect of physical exercise on melatonin secretion and the effect of this compound supplementation on exercise-induced oxidative stress in athletes. Evidence shows that intense exercises disturb antioxidant status of competitive athletes, whereas supplementation with melatonin strengthens antioxidant status in trained athletes in various sports as the compound showed high potency in reduction of the oxidative stress and inflammation markers generated during intense and prolonged exercise.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.