Evidence map›Paper›PMID 34470078›Full record

ArticleStatistics in medicine2021

Avoiding bias in self-controlled case series studies of coronavirus disease 2019.

Osvaldo Fonseca-Rodríguez, Anne-Marie Fors Connolly, Ioannis Katsoularis, Krister Lindmark, Paddy Farrington

Abstract read
In one paragraph

Article in Statistics in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Osvaldo Fonseca-RodríguezDepartment of Clinical Microbiology, Umeå University, Umeå, Sweden.
Anne-Marie Fors ConnollyDepartment of Clinical Microbiology, Umeå University, Umeå, Sweden.ORCID 0000-0001-9215-4047
Ioannis KatsoularisDepartment of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Krister LindmarkDepartment of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Paddy FarringtonSchool of Mathematics and Statistics, The Open University, Milton Keynes, UK.ORCID 0000-0002-7148-2612

Funding

Base Unit ALF-funding RV-939769Central ALF-fundingRegion Vasterbotten RV-836351Strategic funding 2020 Dept Clin Microbiology, Umeå UniversityStroke Research in Northern Sweden, MIMS
6 · The paper itself

Abstract

Many studies, including self-controlled case series (SCCS) studies, are being undertaken to quantify the risks of complications following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19). One such SCCS study, based on all COVID-19 cases arising in Sweden over an 8-month period, has shown that SARS-CoV-2 infection increases the risks of AMI and ischemic stroke. Some features of SARS-CoV-2 infection and COVID-19, present in this study and likely in others, complicate the analysis and may introduce bias. In the present paper we describe these features, and explore the biases they may generate. Motivated by data-based simulations, we propose methods to reduce or remove these biases.

Indexed as

COVID-19StrokeBiasHumansSARS-CoV-2Swedenbiascardiovascular diseaseCOVID-19epidemiological methodsmortalityself-controlled case series

Identifiers

PMID34470078
PMCPMC8661887

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.