Evidence map›Paper›PMID 34469969›Full record

ArticleOptics letters2021

Multimodal high-resolution embryonic imaging with light sheet fluorescence microscopy and optical coherence tomography.

Behzad Khajavi, Ruijiao Sun, Harshdeep Singh Chawla, Henry H Le, Manmohan Singh, Alexander W Schill, Mary E Dickinson, David Mayerich, Kirill V Larin

Open access · greenAbstract read
In one paragraph

Article in Optics letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Behzad Khajavi
Ruijiao Sun
Harshdeep Singh Chawla
Henry H Le
Manmohan Singh
Alexander W Schill
Mary E Dickinson
David Mayerich
Kirill V Larin
University of Houston · USBaylor College of Medicine · US

Funding

Research Programming ModuleP30EY007551 · NEI · UNIVERSITY OF HOUSTON · PI LAURA J. FRISHMAN · 1988 to 2026
$16.4M
Structural and Molecular Phenotyping of Embryonic Development through Multi-Modal Optical ImagingR01HL146745 · NHLBI · UNIVERSITY OF HOUSTON · PI MAYERICH, DAVID · 2019 to 2023
$3.7M
Biomechanics of early mammalian cardiogenesisR01HD096335 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI LARINA, IRINA · 2018 to 2022
$2.8M
Prenatal alcohol/cannabinoid co-exposures and fetal brain developmentR01AA028406 · NIAAA · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI LARIN, KIRILL V, MIRANDA, RAJESH C · 2020 to 2024
$2.6M
NEI NIH HHS P30 EY007551NHLBI NIH HHS R01 HL146745NIAAA NIH HHS R01 AA028406NICHD NIH HHS R01 HD096335
6 · The paper itself

Abstract

A high-resolution imaging system combining optical coherence tomography (OCT) and light sheet fluorescence microscopy (LSFM) was developed. LSFM confined the excitation to only the focal plane, removing the out of plane fluorescence. This enabled imaging a murine embryo with higher speed and specificity than traditional fluorescence microscopy. OCT gives information about the structure of the embryo from the same plane illuminated by LSFM. The co-planar OCT and LSFM instrument was capable of performing co-registered functional and structural imaging of mouse embryos simultaneously.

Indexed as

Tomography, Optical CoherenceAnimalsMiceMicroscopy, Fluorescence

Identifiers

PMID34469969
PMCPMC8903154
OpenAlexW3184582020

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.