Evidence map›Paper›PMID 34469814›Full record

ReviewNeuroImage2021

Recent developments in representations of the connectome.

Janine D Bijsterbosch, Sofie L Valk, Danhong Wang, Matthew F Glasser

Abstract readReview
In one paragraph

Review in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
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  5. Article
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  9. Article
  10. The Prediction of Brain Activity from Connectivity: Advances and Applications.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024
    Review
  11. Article
  12. Co-representation of Functional Brain Networks Is Shaped by Cortical Myeloarchitecture and Reveals Individual Behavioral Ability.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  13. Time-varying functional connectivity as Wishart processes.Imaging neuroscience (Cambridge, Mass.) · 2024
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Janine D BijsterboschDepartment of Radiology, Washington University School of Medicine, Saint Louis, MO, 63110, USA. Electronic address: janine.bijsterbosch@wustl.edu.
Sofie L ValkMax Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; INM-7, Forschungszentrum Jülich, Jülich, Germany.
Danhong WangAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Matthew F GlasserDepartment of Radiology, Washington University School of Medicine, Saint Louis, MO, 63110, USA; Department of Neuroscience, Washington University School of Medicine, Saint Louis, Missouri, 63110, USA.

Funding

RECONSTRUCTIONS AND REPRESENTATIONS OF CEREBRAL CORTEXR01MH060974 · NIMH · WASHINGTON UNIVERSITY · PI VAN ESSEN, DAVID C · 1999 to 2024
$12.7M
Training OPportunities in Translational Imaging Education and Research (TOP-TIER)T32EB021955 · NIBIB · WASHINGTON UNIVERSITY · PI Hongyu An, Joseph Edward Ippolito · 2017 to 2026
$2.4M
Understanding overlap in resting state fMRI networks at the single cell level: a cross-species approachR34NS118618 · NINDS · WASHINGTON UNIVERSITY · PI BIJSTERBOSCH, JANINE DIANE, SNYDER, LAWRENCE H · 2020 to 2020
$709k
NIBIB NIH HHS T32 EB021955NIMH NIH HHS R01 MH060974NINDS NIH HHS R34 NS118618
6 · The paper itself

Abstract

Research into the human connectome (i.e., all connections in the human brain) with the use of resting state functional MRI has rapidly increased in popularity in recent years, especially with the growing availability of large-scale neuroimaging datasets. The goal of this review article is to describe innovations in functional connectome representations that have come about in the past 8 years, since the 2013 NeuroImage special issue on 'Mapping the Connectome'. In the period, research has shifted from group-level brain parcellations towards the characterization of the individualized connectome and of relationships between individual connectomic differences and behavioral/clinical variation. Achieving subject-specific accuracy in parcel boundaries while retaining cross-subject correspondence is challenging, and a variety of different approaches are being developed to meet this challenge, including improved alignment, improved noise reduction, and robust group-to-subject mapping approaches. Beyond the interest in the individualized connectome, new representations of the data are being studied to complement the traditional parcellated connectome representation (i.e., pairwise connections between distinct brain regions), such as methods that capture overlapping and smoothly varying patterns of connectivity ('gradients'). These different connectome representations offer complimentary insights into the inherent functional organization of the brain, but challenges for functional connectome research remain. Interpretability will be improved by future research towards gaining insights into the neural mechanisms underlying connectome observations obtained from functional MRI. Validation studies comparing different connectome representations are also needed to build consensus and confidence to proceed with clinical trials that may produce meaningful clinical translation of connectome insights.

Indexed as

BrainConnectomeHumansIndividualityMagnetic Resonance ImagingNerve NetNeuroimagingConnectomeFunctional connectivityFunctional MRIIndividual variabilityResting state

Identifiers

PMID34469814
PMCPMC8842504

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.