Evidence map›Paper›PMID 34469725›Full record

ArticleCell reports2021

Long-term depression links amyloid-β to the pathological hyperphosphorylation of tau.

Henry B C Taylor, Nigel J Emptage, Alexander F Jeans

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
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  6. CaCell reports · 2025
    Article
  7. Article
  8. TargetingInternational journal of molecular sciences · 2024
    Review
  9. Article
  10. Amyloid-βiScience · 2023
    Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Henry B C TaylorDepartment of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK.
Nigel J EmptageDepartment of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK. Electronic address: nigel.emptage@pharm.ox.ac.uk.
Alexander F JeansDepartment of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK. Electronic address: alexander.jeans@pharm.ox.ac.uk.
University of Oxford · GB

Funding

Biotechnology and Biological Sciences Research Council BB/J018724/1Medical Research Council G0501572Medical Research Council G0802812
6 · The paper itself

Abstract

In Alzheimer's disease, soluble oligomers of the amyloid-β peptide (Aβ

Indexed as

Long-Term Synaptic DepressionAlzheimer DiseaseAmyloid beta-PeptidesAnimalsExcitatory Postsynaptic PotentialsFemaleGlutamic AcidHippocampusIn Vitro TechniquesMaleMiceMice, Inbred C57BLPeptide FragmentsPhosphorylationRatsRats, WistarAmyloid beta-Peptidesamyloid beta-protein (1-42)Glutamic AcidMapt protein, mouseMapt protein, ratPeptide FragmentsReceptors, N-Methyl-D-Aspartatetau ProteinsAlzheimer’s diseaseamyloid-βlong-term depressionneurotransmitter releasephosphorylationtau

Identifiers

PMID34469725
PMCPMC8424646
OpenAlexW3197999746

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.