ArticleActa paediatrica (Oslo, Norway : 1992)2022
Birth outcomes between 22 and 26 weeks' gestation in national population-based cohorts from Sweden, England and France.
Article in Acta paediatrica (Oslo, Norway : 1992), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Global inequities in the survival of extremely preterm infants: a systematic review and meta-analysis.BMC pediatrics · 2025Pooled it
- Outcomes at 21 weeks' gestation: a case series with neurodevelopmental follow-up.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Assessment of survival and neonatal morbidity rates of very low birth weight infants in Türkiye: Turkish Neonatal Society SECRETS (TNS-SECRETS) study.Scientific reports · 2026Observational
- Ethical challenges and moral conflicts in periviability prenatal counseling: a scoping review of healthcare professionals' perspectives.BMC medical ethics · 2026Article
- End-of-life circumstances and unanticipated deaths in a neonatal intensive care unit: a retrospective analysis.BMC palliative care · 2026Article
- Implementation of developmental care in routine NICU practice and early clinical outcomes in preterm infants.Frontiers in pediatrics · 2026Article
- Mortality and Neurodevelopmental Outcome in an Italian Cohort of Very Low Birth Weight Infants.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Outcomes of Infants Born at 21 Weeks' Gestational Age.JAMA network open · 2025Article
- The Impact of Preterm Birth on Parents' Mental Health and the Role of Family-Centred Interventions: A Narrative Review.Children (Basel, Switzerland) · 2025Review
- Changing Dynamics of Management in Fetus Near Viability at 23 Weeks to a Successful Outcome.Journal of obstetrics and gynaecology of India · 2025Article
- Intensity of perinatal care for extreme preterm births and neurodevelopmental outcomes at age 5½: the EPIPAGE-2 cohort study.BMJ paediatrics open · 2025Article
- Considerations for obstetric management of births 22-25 weeks' gestation.Journal of perinatology : official journal of the California Perinatal Association · 2025Review
- It's the little things. A framework and guidance for programs to care for infants 22-23 weeks' gestational age.Journal of perinatology : official journal of the California Perinatal Association · 2025Review
- Impact of maternal prepregnancy body mass index on neonatal outcomes following extremely preterm birth.Obesity (Silver Spring, Md.) · 2025Article
- Centralisation of extremely preterm births and decreased early postnatal mortality in Sweden, 2004-2007 versus 2014-2016.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Article
- A structured comparison and reflection on international position statements and professional guidance for the management of periviable infants.Frontiers in pediatrics · 2025Review
- Novel biomarkers of preterm brain injury from blood transcriptome in sheep model of intrauterine asphyxia.Pediatric research · 2024Article
- Identification of Neonatal Factors Predicting Pre-Discharge Mortality in Extremely Preterm or Extremely Low Birth Weight Infants: A Historical Cohort Study.Children (Basel, Switzerland) · 2024Article
- Neonatal Mortality Disparities by Gestational Age in European Countries.JAMA network open · 2024Article
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Authors and funding
15 authors.
Funding
Abstract
aimWe investigated the timing of survival differences and effects on morbidity for foetuses alive at maternal admission to hospital delivered at 22 to 26 weeks' gestational age (GA).
methodsData from the EXPRESS (Sweden, 2004-07), EPICure-2 (England, 2006) and EPIPAGE-2 (France, 2011) cohorts were harmonised. Survival, stratified by GA, was analysed to 112 days using Kaplan-Meier analyses and Cox regression adjusted for population and pregnancy characteristics; neonatal morbidities, survival to discharge and follow-up and outcomes at 2-3 years of age were compared.
resultsAmong 769 EXPRESS, 2310 EPICure-2 and 1359 EPIPAGE-2 foetuses, 112-day survival was, respectively, 28.2%, 10.8% and 0.5% at 22-23 weeks' GA; 68.5%, 40.0% and 23.6% at 24 weeks; 80.5%, 64.8% and 56.9% at 25 weeks; and 86.6%, 77.1% and 74.4% at 26 weeks. Deaths were most marked in EPIPAGE-2 before 1 day at 22-23 and 24 weeks GA. At 25 weeks, survival varied before 28 days; differences at 26 weeks were minimal. Cox analyses were consistent with the Kaplan-Meier analyses. Variations in morbidities were not clearly associated with survival.
conclusionDifferences in survival and morbidity outcomes for extremely preterm births are evident despite adjustment for background characteristics. No clear relationship was identified between early mortality and later patterns of morbidity.
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