Evidence map›Paper›PMID 34469548›Full record

ArticleMolecular biology and evolution2021

A Daily-Updated Database and Tools for Comprehensive SARS-CoV-2 Mutation-Annotated Trees.

Jakob McBroome, Bryan Thornlow, Angie S Hinrichs, Alexander Kramer, Nicola De Maio, Nick Goldman, David Haussler, Russell Corbett-Detig, Yatish Turakhia

Abstract read
In one paragraph

Article in Molecular biology and evolution, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed.

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  16. A Pandemic-Scale Ancestral Recombination Graph for SARS-CoV-2.bioRxiv : the preprint server for biology · 2025
    Article
  17. Article
  18. Article
  19. Article
  20. UShER-TB: Scalable, Comprehensive, Accessible Phylogenomic Analysis ofmedRxiv : the preprint server for health sciences · 2025
    Article

27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Jakob McBroomeDepartment of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, CA, USA.
Bryan ThornlowDepartment of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, CA, USA.
Angie S HinrichsGenomics Institute, University of California Santa Cruz, Santa Cruz, CA, USA.
Alexander KramerDepartment of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, CA, USA.
Nicola De MaioEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Cambridge, United Kingdom.
Nick GoldmanEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Cambridge, United Kingdom.ORCID 0000-0001-8486-2211
David HausslerDepartment of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, CA, USA.
Russell Corbett-DetigDepartment of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, CA, USA.
Yatish TurakhiaDepartment of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, CA, USA.

Funding

The UCSC Genome BrowserU41HG002371 · NHGRI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI KENT, WILLIAM JAMES · 2012 to 2021
$36.6M
Origins, Functional, and Evolutionary Consequences of Genomic VariationR35GM128932 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI Russell Corbett-Detig · 2018 to 2026
$3.2M
Enabling Comparative PangenomicsR01HG010485 · NHGRI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI HAUSSLER, DAVID H, MARTIN, FERGAL JAMES · 2020 to 2023
$2.6M
UC Santa Cruz Training Program In Genomic SciencesT32HG008345 · NHGRI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI BROOKS, ANGELA NORIE, GREEN, RICHARD EDWARD · 2015 to 2020
$1.4M
Evolutionary dynamics of tRNA genesF31HG010584 · NHGRI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI THORNLOW, BRYAN PATRICK · 2019 to 2021
$86k
CDC HHS BAA 200-2021-11554NHGRI NIH HHS 5U41HG002371NHGRI NIH HHS F31 HG010584NHGRI NIH HHS R01 HG010485NHGRI NIH HHS T32 HG008345NHGRI NIH HHS U41 HG002371NIGMS NIH HHS R35 GM128932NIH HHS 5R01HG010485
6 · The paper itself

Abstract

The vast scale of SARS-CoV-2 sequencing data has made it increasingly challenging to comprehensively analyze all available data using existing tools and file formats. To address this, we present a database of SARS-CoV-2 phylogenetic trees inferred with unrestricted public sequences, which we update daily to incorporate new sequences. Our database uses the recently proposed mutation-annotated tree (MAT) format to efficiently encode the tree with branches labeled with parsimony-inferred mutations, as well as Nextstrain clade and Pango lineage labels at clade roots. As of June 9, 2021, our SARS-CoV-2 MAT consists of 834,521 sequences and provides a comprehensive view of the virus' evolutionary history using public data. We also present matUtils-a command-line utility for rapidly querying, interpreting, and manipulating the MATs. Our daily-updated SARS-CoV-2 MAT database and matUtils software are available at http://hgdownload.soe.ucsc.edu/goldenPath/wuhCor1/UShER_SARS-CoV-2/ and https://github.com/yatisht/usher, respectively.

Indexed as

Evolution, MolecularPhylogenySARS-CoV-2COVID-19HumansMutationSoftwareCOVID-19genomic surveillanceSARS-CoV-2 phylogenetics

Identifiers

PMID34469548
PMCPMC8662617

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.