ArticleMolecular biology and evolution2021
A New World Monkey Resembles Human in Bitter Taste Receptor Evolution and Function via a Single Parallel Amino Acid Substitution.
Article in Molecular biology and evolution, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Deciphering genetic adaptations of Old World camels through comparative genomic analyses across all camelid species.iScience · 2025Article
- Rapid expansion and specialization of the TAS2R bitter taste receptor family in amphibians.PLoS genetics · 2025Article
- The Remarkable Diversity of Vertebrate Bitter Taste Receptors: Recent Advances in Genomic and Functional Studies.International journal of molecular sciences · 2024Review
- Relationships between Bitter Taste Receptor Gene Evolution, Diet, and Gene Repertoire in Primates.Genome biology and evolution · 2024Article
- Molecular mechanisms of adaptive evolution in wild animals and plants.Science China. Life sciences · 2023Review
- Article
- Functional Diversity and Evolution of Bitter Taste Receptors in Egg-Laying Mammals.Molecular biology and evolution · 2022Article
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bitter taste receptors serve as a vital component in the defense system against toxin intake by animals, and the family of genes encoding these receptors has been demonstrated, usually by family size variance, to correlate with dietary preference. However, few systematic studies of specific Tas2R to unveil their functional evolution have been conducted. Here, we surveyed Tas2R16 across all major clades of primates and reported a rare case of a convergent change to increase sensitivity to β-glucopyranosides in human and a New World monkey, the white-faced saki. Combining analyses at multiple levels, we demonstrate that a parallel amino acid substitution (K172N) shared by these two species is responsible for this functional convergence of Tas2R16. Considering the specialized feeding preference of the white-faced saki, the K172N change likely played an important adaptive role in its early evolution to avoid potentially toxic cyanogenic glycosides, as suggested for the human TAS2R16 gene.
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Registered trials
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