Evidence map›Paper›PMID 34469481›Full record

ArticlePloS one2021

Recovery of the maternal skeleton after lactation is impaired by advanced maternal age but not by reduced IGF availability in the mouse.

Monika D Rogowska, Uriel N V Pena, Nimrat Binning, Julian K Christians

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Monika D RogowskaDepartment of Biological Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.
Uriel N V PenaDepartment of Biological Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.
Nimrat BinningDepartment of Biological Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.
Julian K ChristiansDepartment of Biological Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.ORCID 0000-0003-1797-0591
Simon Fraser University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLactation results in substantial maternal bone loss that is recovered following weaning. However, the mechanisms underlying this recovery, and in particular the role of insulin-like growth factor 1 (IGF-I), is not clear. Furthermore, there is little data regarding whether recovery is affected by advanced maternal age.

methodsUsing micro-computed tomography, we studied bone recovery following lactation in mice at 2, 5 and 7 months of age. We also investigated the effects of reduced IGF-I availability using mice lacking PAPP-A2, a protease of insulin-like growth factor binding protein 5 (IGFBP-5).

resultsIn 2 month old mice, lactation affected femoral trabecular and cortical bone, but only cortical bone showed recovery 3 weeks after weaning. This recovery was not affected by deletion of the Pappa2 gene. The amount of trabecular bone was reduced in 5 and 7 month old mice, and was not further reduced by lactation. However, the recovery of cortical bone was impaired at 5 and 7 months compared with at 2 months.

conclusionsRecovery of the maternal skeleton after lactation is impaired in moderately-aged mice compared with younger mice. Our results may be relevant to the long-term effects of breastfeeding on the maternal skeleton in humans, particularly given the increasing median maternal age at childbearing.

Indexed as

Maternal AgeAge FactorsAnimalsBone DensityBone Diseases, MetabolicCancellous BoneCarrier ProteinsCortical BoneDisease Models, AnimalFemaleInsulin-Like Growth Factor ILactationMiceMice, KnockoutOsteogenesisPregnancyCarrier ProteinsIGFBP5-interacting protein, mouseinsulin-like growth factor-1, mouseInsulin-Like Growth Factor IPAPPA2 protein, mousePregnancy-Associated Plasma Protein-A

Identifiers

PMID34469481
PMCPMC8409645
OpenAlexW3197822371

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.