Evidence map›Paper›PMID 34469242›Full record

ArticleJournal of virology2021

Evaluation of a New Viral Vaccine Vector in Mice and Rhesus Macaques: J Paramyxovirus Expressing Hemagglutinin of Influenza A Virus H5N1.

Mathew Abraham, Ashley C Beavis, Peng Xiao, Francois J Villinger, Zhuo Li, Cheryl A Jones, S Mark Tompkins, Biao He

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Mathew AbrahamDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgiagrid.213876.9, Athens, Georgia, USA.
Ashley C BeavisDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgiagrid.213876.9, Athens, Georgia, USA.
Peng XiaoNew Iberia Research Center, University of Louisiana at Lafayette, New Iberia, Louisiana, USA.ORCID 0000-0002-5308-8400
Francois J VillingerNew Iberia Research Center, University of Louisiana at Lafayette, New Iberia, Louisiana, USA.
Zhuo LiDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgiagrid.213876.9, Athens, Georgia, USA.
Cheryl A JonesDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgiagrid.213876.9, Athens, Georgia, USA.
S Mark TompkinsDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgiagrid.213876.9, Athens, Georgia, USA.ORCID 0000-0002-1523-5588
Biao HeDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgiagrid.213876.9, Athens, Georgia, USA.ORCID 0000-0001-8336-7171
University of Georgia · USUniversity of Louisiana at Lafayette · US

Funding

Pathogenesis of JeilongvirusR01AI128924 · NIAID · UNIVERSITY OF GEORGIA · PI HE, BIAO · 2017 to 2021
$2.4M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI128924NIAID NIH HHS R01 AI128924
6 · The paper itself

Abstract

H5N1, an avian influenza virus, is known to circulate in many Asian countries, such as Bangladesh, China, Cambodia, Indonesia, and Vietnam. The current FDA-approved H5N1 vaccine has a moderate level of efficacy. A safe and effective vaccine is needed to prevent outbreaks of highly pathogenic avian influenza (HPAI) H5N1 in humans. Nonsegmented negative-sense single-stranded viruses (NNSVs) are widely used as a vector to develop vaccines for humans, animals, and poultry. NNSVs stably express foreign genes without integrating with the host genome. J paramyxovirus (JPV) is a nonsegmented negative-strand RNA virus and a member of the proposed genus

Indexed as

AnimalsCell LineChlorocebus aethiopsCricetinaeDogsFemaleHemagglutinin Glycoproteins, Influenza VirusHumansInfluenza A Virus, H5N1 SubtypeInfluenza VaccinesMacaca mulattaMaleMiceMice, Inbred BALB COrthomyxoviridae InfectionsParamyxovirinaeHemagglutinin Glycoproteins, Influenza VirusInfluenza VaccinesH5N1J paramyxovirusvaccine

Identifiers

PMID34469242
PMCPMC8549524
OpenAlexW3196340607

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.