ArticleApplied and environmental microbiology2021
Transcriptomic Responses to Coaggregation between Streptococcus gordonii and Streptococcus oralis.
Article in Applied and environmental microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Effect of a sodium fluoride rinse on the composition of early oral biofilms formed in situ on enamel and dentine.Clinical oral investigations · 2026Trial
- Multifunctional dual drug-loaded Gel-Alg/MINO/MEL composite hydrogel for combating three-dimensional multi-species biofilm and experimental periodontitis treatment.Clinical oral investigations · 2026Article
- An innovative microplate-based method to measure coaggregation between a model pair of coaggregating oral bacteria.Journal of oral microbiology · 2026Article
- The Quorum Sensing-Controlled Competence Regulon Drives HACS infectious diseases · 2025Article
- The Infant Oral Microbiome: Developmental Dynamics, Modulating Factors, and Implications for Oral and Systemic Health.International journal of molecular sciences · 2025Review
- Genomic and functional insights into commensal streptococci with anti-pneumococcal activity.BMC genomics · 2025Article
- Intestinal Microbiota in Early Life: Latest Findings Regarding the Role of Probiotics as a Treatment Approach for Dysbiosis.Nutrients · 2025Review
- Combined Analysis of Transcriptomes and Metabolomes Reveals Key Genes and Substances That Affect the Formation of a Multi-Species Biofilm by Nine Gut Bacteria.Microorganisms · 2025Article
- Shaping oral and intestinal microbiota and the immune system during the first 1,000 days of life.Frontiers in pediatrics · 2025Review
- Correlation between oral microbiota and dry socket at different time periods on tooth extraction.Journal of oral microbiology · 2025Article
- Gardnerella vaginalis, Fannyhessea vaginae, and Prevotella bivia Strongly Influence Each Other's Transcriptome in Triple-Species Biofilms.Microbial ecology · 2024Article
- Mechanisms of microbial co-aggregation in mixed anaerobic cultures.Applied microbiology and biotechnology · 2024Review
- Social networking at the microbiome-host interface.Infection and immunity · 2023Review
- Association of polymicrobial interactions with dental caries development and prevention.Frontiers in microbiology · 2023Review
- The Oral Microbiota: Community Composition, Influencing Factors, Pathogenesis, and Interventions.Frontiers in microbiology · 2022Review
- A gut aging clock using microbiome multi-view profiles is associated with health and frail risk.Gut microbesArticle
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 5 countries.
Funding
Abstract
Cell-cell adhesion between oral bacteria plays a key role in the development of polymicrobial communities such as dental plaque. Oral streptococci such as Streptococcus gordonii and Streptococcus oralis are important early colonizers of dental plaque and bind to a wide range of different oral microorganisms, forming multispecies clumps or "coaggregates." S. gordonii actively responds to coaggregation by regulating gene expression. To further understand these responses, we assessed gene regulation in S. gordonii and S. oralis following coaggregation in 25% human saliva. Coaggregates were formed by mixing, and after 30 min, RNA was extracted for dual transcriptome sequencing (RNA-Seq) analysis. In S. oralis, 18 genes (6 upregulated and 12 downregulated) were regulated by coaggregation. Significantly downregulated genes encoded functions such as amino acid and antibiotic biosynthesis, ribosome, and central carbon metabolism. In total, 28 genes were differentially regulated in Streptococcus gordonii (25 upregulated and 3 downregulated). Many genes associated with transporters and a two-component (NisK/SpaK) regulatory system were upregulated following coaggregation. Our comparative analyses of S. gordonii
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.