Evidence map›Paper›PMID 34469182›Full record

ArticleJournal of clinical microbiology2021

Xpert MTB/RIF Ultra Is Highly Sensitive for the Diagnosis of Tuberculosis Lymphadenitis in a High-HIV Setting.

Stephanie Minnies, Byron W P Reeve, Loren Rockman, Georgina Nyawo, Charissa C Naidoo, Natasha Kitchin, Cornelia Rautenbach, Colleen A Wright, Andrew Whitelaw, Pawel Schubert and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of clinical microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Diagnostic accuracy of Xpert MTB/RIF Ultra for detecting pulmonary tuberculosis and rifampicin resistance: a systematic review and meta-analysis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Pooled it
  3. Article
  4. Observational
  5. More thanThorax · 2023
    Article
  6. African journal of infectious diseases · 2023
    Article
  7. Diagnosing Tuberculosis: What Do New Technologies Allow Us to (Not) Do?Respiration; international review of thoracic diseases · 2022
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Stephanie Minnies *DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch Universitygrid.11956.3a, Cape Town, Republic of South Africa.
Byron W P Reeve *DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch Universitygrid.11956.3a, Cape Town, Republic of South Africa.
Loren RockmanDSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch Universitygrid.11956.3a, Cape Town, Republic of South Africa.
Georgina NyawoDSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch Universitygrid.11956.3a, Cape Town, Republic of South Africa.
Charissa C NaidooDSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch Universitygrid.11956.3a, Cape Town, Republic of South Africa.
Natasha KitchinDepartment of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch Universitygrid.11956.3a, Cape Town, Republic of South Africa.
Cornelia RautenbachDivision of Medical Microbiology, Faculty of Medicine and Health Sciences, Stellenbosch Universitygrid.11956.3a, Cape Town, Republic of South Africa.
Colleen A WrightDivision of Anatomical Pathology, Faculty of Medicine and Health Sciences, Stellenbosch Universitygrid.11956.3a, Cape Town, Republic of South Africa.
Andrew WhitelawDivision of Medical Microbiology, Faculty of Medicine and Health Sciences, Stellenbosch Universitygrid.11956.3a, Cape Town, Republic of South Africa.
Pawel SchubertNational Health Laboratory Services, Cape Town, Republic of South Africa.
Robin M WarrenDSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch Universitygrid.11956.3a, Cape Town, Republic of South Africa.
Grant TheronDSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch Universitygrid.11956.3a, Cape Town, Republic of South Africa.
South African Medical Research Council · ZAStellenbosch University · ZA

Funding

Rapid Research for Diagnostics Development in TB Network (R2D2 TB Network)U01AI152087 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CATTAMANCHI, ADITHYA, DENKINGER, CLAUDIA MARIA · 2020 to 2024
$19.3M
NIAID NIH HHS U01 AI152087NIH HHS U01AI152087
6 · The paper itself

Abstract

Tuberculosis lymphadenitis (TBL) is the most common extrapulmonary tuberculosis (EPTB) manifestation. Xpert MTB/RIF Ultra (Ultra) is a World Health Organization-endorsed diagnostic test, but performance data for TBL, including on noninvasive specimens, are limited. Fine-needle aspiration biopsy specimens (FNABs) from outpatients (≥18 years) with presumptive TBL (

Indexed as

Antibiotics, AntitubercularHIV InfectionsLymphadenitisMycobacterium tuberculosisTuberculosis, Lymph NodeTuberculosis, PulmonaryHumansRifampinSensitivity and SpecificityAntibiotics, AntitubercularRifampindiagnostic accuracytuberculosis lymphadenitisXpert MTB/RIF Ultra

Identifiers

PMID34469182
PMCPMC8601227
OpenAlexW3167534068

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.