Evidence map›Paper›PMID 34469172›Full record

ArticleJournal of proteome research2021

Rabbit Antidiethoxyphosphotyrosine Antibody, Made by Single B Cell Cloning, Detects Chlorpyrifos Oxon-Modified Proteins in Cultured Cells and Immunopurifies Modified Peptides for Mass Spectrometry.

Seda Onder, Marco van Grol, Alex Fidder, Gaoping Xiao, Daan Noort, Udaya Yerramalla, Ozden Tacal, Lawrence M Schopfer, Oksana Lockridge

Open access · bronzeAbstract read
In one paragraph

Article in Journal of proteome research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Seda OnderDepartment of Biochemistry, School of Pharmacy, Hacettepe University, Ankara 06100, Turkey.
Marco van GrolTNO Organisation for Applied Scientific Research, 2280 AA Rijswijk, The Netherlands.
Alex FidderTNO Organisation for Applied Scientific Research, 2280 AA Rijswijk, The Netherlands.
Gaoping XiaoSyd Labs, Inc., Hopkinton, Massachusetts 01748, United States.
Daan NoortTNO Organisation for Applied Scientific Research, 2280 AA Rijswijk, The Netherlands.ORCID https://orcid.org/0000-0001-9267-814X
Udaya YerramallaPrecision Antibody, Columbia, Maryland 21045, United States.
Ozden TacalDepartment of Biochemistry, School of Pharmacy, Hacettepe University, Ankara 06100, Turkey.
Lawrence M SchopferEppley Institute, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.ORCID https://orcid.org/0000-0002-1785-9247
Oksana LockridgeEppley Institute, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.ORCID https://orcid.org/0000-0002-8345-3640
Netherlands Organisation for Applied Scientific Research · NLHacettepe University · TRUniversity of Nebraska Medical Center · US

Funding

UNMC/EPPLEY CANCER CENTER SUPPORT GRANTP30CA036727 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI James Eudy · 1985 to 2026
$55.0M
Crosslinking Action of Chlorpyrifos Oxon as Mechanism of Chronic IllnessR21ES030132 · NIEHS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI LOCKRIDGE, OKSANA · 2020 to 2021
$419k
NCI NIH HHS P30 CA036727NIEHS NIH HHS R21 ES030132
6 · The paper itself

Abstract

Chronic low-dose exposure to organophosphorus pesticides is associated with the risk of neurodegenerative disease. The mechanism of neurotoxicity is independent of acetylcholinesterase inhibition. Adducts on tyrosine, lysine, threonine, and serine can occur after exposure to organophosphorus pesticides, the most stable being adducts on tyrosine. Rabbit monoclonal 1C6 to diethoxyphosphate-modified tyrosine (depY) was created by single B cell cloning. The amino acid sequence and binding constant (

Indexed as

Neurodegenerative DiseasesPesticidesAcetylcholinesteraseAnimalsB-LymphocytesCells, CulturedChlorpyrifosChromatography, LiquidCloning, MolecularMiceOrganophosphorus CompoundsPeptidesTandem Mass SpectrometryAcetylcholinesteraseChlorpyrifosO,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphateOrganophosphorus CompoundsPeptidesPesticidesdiethoxyphosphotyrosinemass spectrometryN2a neuroblastomaProtein Prospectorrabbit monoclonalSH-SY5Ysingle B cell cloning

Identifiers

PMID34469172
PMCPMC8491160
OpenAlexW3198372169

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.