Evidence map›Paper›PMID 34469142›Full record

ArticleBiochemistry2021

The Luminescent Conjugated Oligothiophene h-FTAA Attenuates the Toxicity of Different Aβ Species.

Linnea Sandin, Simon Sjödin, Ann-Christin Brorsson, Katarina Kågedal, Livia Civitelli

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Linnea SandinExperimental Pathology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping 581 83, Sweden.
Simon SjödinExperimental Pathology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping 581 83, Sweden.
Ann-Christin BrorssonDivision of Molecular Biotechnology, Department of Physics, Chemistry and Biology, Linköping University, Linköping 581 83, Sweden.
Katarina KågedalExperimental Pathology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping 581 83, Sweden.
Livia CivitelliExperimental Pathology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping 581 83, Sweden.ORCID 0000-0003-2399-1436
Linköping University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prevailing opinion is that prefibrillar β-amyloid (Aβ) species, rather than end-stage amyloid fibrils, cause neuronal dysfunction in Alzheimer's disease, although the mechanisms behind Aβ neurotoxicity remain to be elucidated. Luminescent conjugated oligothiophenes (LCOs) exhibit spectral properties upon binding to amyloid proteins and have previously been reported to change the toxicity of Aβ

Indexed as

AcetatesAmyloidAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAmyloidogenic ProteinsFluorescent DyesHumansKineticsLuminescencePeptide FragmentsProtein AggregatesStaining and LabelingThiophenesAcetatesAmyloidAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAmyloidogenic ProteinsFluorescent Dyespentamer formyl thiophene acetic acidPeptide FragmentsProtein AggregatesThiophenes

Identifiers

PMID34469142
PMCPMC8459454
OpenAlexW3198176649

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.